Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | F2R | P25116 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13071528 | 0.92 | DPP4 (0.36) | ACEMEN1KMT2ALMNAF2R | |
| SCHEMBL12831754 | 0.91 | ACE (0.41) | ACELMNASMN1; SMN2P2RY12F2 | |
| SCHEMBL13071404 | 0.91 | ALDH1A1 (0.39) | ACELMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL13071880 | 0.89 | UBE2M (0.34) | ACEF2RSMN1; SMN2ALDH1A1TACR1 | |
| SCHEMBL13071526 | 0.88 | UBE2M (0.35) | ACEF2RF2F10 | |
| SCHEMBL13071527 | 0.87 | DPP4 (0.39) | ACELMNASMN1; SMN2P2RY12ALDH1A1 | |
| SCHEMBL13071900 | 0.86 | TACR1 (0.36) | ACENPSR1USP2MEN1KMT2A | |
| SCHEMBL13072094 | 0.86 | USP2 (0.34) | ACENPSR1USP2MEN1KMT2A | |
| SCHEMBL13071403 | 0.85 | USP2 (0.34) | ACENPSR1USP2MEN1KMT2A | |
| SCHEMBL13071388 | 0.85 | HTR1A (0.38) | ACELMNASMN1; SMN2ALDH1A1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142842-A9 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |