Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.35 |
| ▸ | OXTR | P30559 | 2/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790964 | 0.91 | PTGES (0.43) | ORAI1PTGESDGAT1 | |
| SCHEMBL3799446 | 0.82 | PTGES (0.52) | ORAI1PTGESMAPK10DGAT1 | |
| SCHEMBL3796320 | 0.78 | PTGES (0.49) | ORAI1PTGES | |
| SCHEMBL13076588 | 0.77 | PBRM1 (0.36) | ORAI1PTGESMEN1KMT2APBRM1 | |
| SCHEMBL13076230 | 0.77 | PTGES (0.43) | PTGES | |
| SCHEMBL3801417 | 0.76 | PTGES (0.48) | PTGESDGAT1 | |
| SCHEMBL3796002 | 0.76 | PTGES (0.43) | ORAI1PTGES | |
| SCHEMBL29662800 | 0.75 | PTGES (0.43) | PTGES | |
| SCHEMBL4784907 | 0.74 | RHEB (0.46) | PTGESMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL3794879 | 0.74 | PTGES (0.47) | ORAI1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |