Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.44 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.44 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.44 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3796469 | 0.80 | POLB (0.52) | POLBTLR8KDM4ERAB9AMEN1 | |
| SCHEMBL19437489 | 0.77 | POLB (0.60) | ACSS2POLBTLR8KDM4EKMT2A | |
| SCHEMBL3797142 | 0.76 | POLB (0.51) | POLBTLR8ALDH1A1SMN1; SMN2 | |
| SCHEMBL13077024 | 0.74 | ACSS2 (0.48) | ACSS2POLBTLR8KDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL21437300 | 0.74 | TRPV1 (0.50) | ACSS2TLR8KDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL21437181 | 0.73 | TRPV1 (0.52) | TLR8KDM4EMAPTTP53 | |
| SCHEMBL15000607 | 0.72 | NPC1 (0.57) | POLBKDM4ERAB9AMEN1KMT2A | |
| SCHEMBL13076797 | 0.72 | POLB (0.49) | ACSS2POLBTLR8ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL21437386 | 0.70 | MAPT (0.51) | ACSS2KDM4EMAPTTP53 | |
| SCHEMBL1520381 | 0.70 | POLB (1.00) | POLBTLR8KDM4ERAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |