Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13499239 | 0.86 | SIGMAR1 (0.66) | ALDH1A1SIGMAR1ACHEKMT2AMEN1 | |
| SCHEMBL14660577 | 0.85 | ALDH1A1 (0.59) | ALDH1A1KDM4EGFERL3MBTL1HPGD | |
| SCHEMBL13182865 | 0.85 | ALDH1A1 (0.59) | ALDH1A1KDM4EGFERL3MBTL1HPGD | |
| SCHEMBL14375364 | 0.83 | SIGMAR1 (0.68) | SIGMAR1ACHE | |
| SCHEMBL14327144 | 0.83 | ALDH1A1 (0.58) | ALDH1A1KDM4EGFERL3MBTL1HPGD | |
| SCHEMBL8267685 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KDM4EGFERL3MBTL1HPGD | |
| SCHEMBL14359428 | 0.81 | MEN1 (0.66) | ALDH1A1KDM4ESIGMAR1KMT2AMEN1 | |
| SCHEMBL2608082 | 0.81 | SIGMAR1 (0.52) | ALDH1A1KDM4ESIGMAR1HPGDACHE | |
| SCHEMBL7792404 | 0.80 | ALDH1A1 (0.67) | ALDH1A1KDM4EGFERL3MBTL1HPGD | |
| SCHEMBL12652357 | 0.80 | ALDH1A1 (0.54) | ALDH1A1KDM4EGFERL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586951-B2 | Morpholine derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2017-03-07 | — | — | US | disclosed |
| US-9586951-B2 | Morpholine derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2017-03-07 | — | — | US | disclosed |
| EP-3042900-A1 | NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF | Fujifilm Corporation (JP) | 2016-07-13 | — | — | EP | disclosed |
| US-20160168139-A1 | NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2016-06-16 | — | — | US | disclosed |
| US-20160168139-A1 | NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2016-06-16 | — | — | US | disclosed |
| US-7838533-B2 | Azaindole inhibitors of MTP and ApoB | MERCK PATENT GMBH (DE) | 2010-11-23 | — | — | US | disclosed |
| US-20090036481-A1 | Novel Azaindole Inhibitors of Mtp and Apob | MERCK PATENT GMBH (DE) | 2009-02-05 | — | — | US | disclosed |
| EP-1771446-B1 | AZAINDOLE INHIBITORS OF MTP AND APOB | MERCK PATENT GMBH (DE) | 2008-06-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036481-A1 | Novel Azaindole Inhibitors of Mtp and Apob | APOB, MTPN, HDLBP | ALDH1A1 3630/4885KDM4E 3429/4885GFER 4099/4885 |
| US-20160168139-A1 | NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF | PRMT7, RBBP7, RER1 | ALDH1A1 2519/4885KDM4E 2666/4885GFER 4267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.