Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28134373 | 0.79 | ALDH1A1 (0.57) | ALDH1A1MAPTL3MBTL1HPGDKMT2A | |
| SCHEMBL13098122 | 0.77 | HPGD (0.45) | ALDH1A1MAPTL3MBTL1HPGDKMT2A | |
| SCHEMBL777869 | 0.76 | MAPT (0.57) | ALDH1A1MAPTL3MBTL1KMT2APOLB | |
| SCHEMBL31554190 | 0.76 | MAPT (0.57) | ALDH1A1MAPTL3MBTL1KMT2APOLB | |
| SCHEMBL607429 | 0.74 | ALDH1A1 (0.47) | ALDH1A1MAPTL3MBTL1KMT2APOLB | |
| SCHEMBL28097007 | 0.72 | ALDH1A1 (0.46) | ALDH1A1MAPTKMT2APOLBPKM | |
| SCHEMBL16752332 | 0.72 | ALDH1A1 (0.46) | ALDH1A1MAPTL3MBTL1KMT2APOLB | |
| SCHEMBL28840713 | 0.72 | MAPT (0.47) | ALDH1A1MAPTL3MBTL1KMT2APOLB | |
| SCHEMBL5936403 | 0.71 | ALDH1A1 (0.52) | ALDH1A1MAPTL3MBTL1KMT2APOLB | |
| SCHEMBL13098120 | 0.71 | ALDH1A1 (0.44) | ALDH1A1MAPTL3MBTL1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461145-B2 | Dibenzoazepine and dibenzooxazepine TRPA1 agonists | JANSSEN PHARMACEUTICA NV (BE) | 2013-06-11 | — | — | US | disclosed |
| US-8461145-B2 | Dibenzoazepine and dibenzooxazepine TRPA1 agonists | JANSSEN PHARMACEUTICA NV (BE) | 2013-06-11 | — | — | US | disclosed |
| US-20100273773-A1 | DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | US | disclosed |
| US-20100273773-A1 | DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | US | disclosed |
| WO-2009071631-A2 | DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273773-A1 | DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS | TRPA1, TRPV1, TRPV2 | ALDH1A1 655/4885MAPT 1080/4885L3MBTL1 3619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.