Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | GPR139 | Q6DWJ6 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11523072 | 0.90 | HTR1A (0.57) | HTR1AADRA2ADRD1SLC6A2SLC6A4 | |
| SCHEMBL7823381 | 0.90 | KMT2A (0.70) | HTR1AADRA2ADRD1SLC6A2SLC6A4 | |
| SCHEMBL9148324 | 0.84 | L3MBTL1 (0.73) | KMT2AMEN1L3MBTL1CES2CES1 | |
| SCHEMBL5161471 | 0.84 | L3MBTL1 (0.64) | KMT2AMEN1HSD11B1L3MBTL1CES2 | |
| SCHEMBL28629704 | 0.83 | MAPT (0.69) | HTR1AADRA2ADRD1SLC6A2SLC6A4 | |
| SCHEMBL12158740 | 0.82 | L3MBTL1 (0.62) | HTR1AADRA2ADRD1SLC6A2SLC6A4 | |
| SCHEMBL13100658 | 0.82 | KMT2A (0.79) | HTR1AADRA2ADRD1SLC6A2SLC6A4 | |
| SCHEMBL11203155 | 0.81 | CES2 (0.56) | HTR1AADRA2ADRD1SLC6A2SLC6A4 | |
| SCHEMBL6169730 | 0.81 | CES2 (0.56) | HTR1AADRA2ADRD1SLC6A2SLC6A4 | |
| SCHEMBL6645336 | 0.81 | AKR1C3 (0.49) | HTR1AADRA2ADRD1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256394-A1 | METHOD FOR THE PREPARATION OF LASOFOXIFENE | ZENTIVA K.S. (CZ) | 2010-10-07 | — | — | US | disclosed |
| US-20100256394-A1 | METHOD FOR THE PREPARATION OF LASOFOXIFENE | ZENTIVA K.S. (CZ) | 2010-10-07 | — | — | US | disclosed |
| WO-2008145075-A2 | METHOD FOR THE PREPARATION OF LASOFOXIFENE AND CRYSTALLINE INTERMEDIATES USED THEREIN | ZENTIVA, A.S. (CZ) | 2008-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256394-A1 | METHOD FOR THE PREPARATION OF LASOFOXIFENE | SRD5A1, SRD5A2, CYP19A1 | HTR1A 147/4885ADRA2A 1670/4885DRD1 652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.