Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Midazolam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 2/20 | 0.52 |
| ▸ | GABRA5 known ✓ | P31644 | 2/20 | 0.52 |
| ▸ | GABRA2 known ✓ | P47869 | 2/20 | 0.52 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.52 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.52 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.52 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.98 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.98 |
| ▸ | DRD3 | P35462 | 2/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | PTAFR | P25105 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Midazolam SCHEMBL29419655 | 1.00 | OPRK1 (0.98) | OPRK1CYP3A4PDE4DDRD3SLC22A1 | |
| Midazolam SCHEMBL41265 | 1.00 | OPRK1 (0.98) | OPRK1CYP3A4PDE4DDRD3SLC22A1 | |
| Midazolam SCHEMBL29445200 | 1.00 | OPRK1 (0.98) | OPRK1CYP3A4PDE4DDRD3SLC22A1 | |
| Midazolam SCHEMBL29565146 | 0.99 | OPRK1 (1.00) | OPRK1CYP3A4PDE4DDRD3SLC22A1 | |
| Midazolam SCHEMBL5783371 | 0.99 | OPRK1 (1.00) | OPRK1CYP3A4PDE4DDRD3SLC22A1 | |
| Midazolam SCHEMBL29735381 | 0.99 | OPRK1 (1.00) | OPRK1CYP3A4PDE4DDRD3SLC22A1 | |
| Midazolam SCHEMBL29480459 | 0.99 | OPRK1 (1.00) | OPRK1CYP3A4PDE4DDRD3SLC22A1 | |
| Midazolam SCHEMBL35061 | 0.99 | OPRK1 (1.00) | OPRK1CYP3A4PDE4DDRD3SLC22A1 | |
| Midazolam SCHEMBL29357425 | 0.99 | OPRK1 (1.00) | OPRK1CYP3A4PDE4DDRD3SLC22A1 | |
| Midazolam SCHEMBL15270674 | 0.98 | OPRK1 (0.98) | OPRK1CYP3A4PDE4DDRD3SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113149992-B | Preparation method and application of midazolam hydrochloride F crystal form | 福安药业集团重庆礼邦药物开发有限公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-116041351-A | Novel midazolam hydrochloride crystal form and preparation method thereof | 成都硕德药业有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-113149992-A | Preparation method and application of midazolam hydrochloride F crystal form | 福安药业集团重庆礼邦药物开发有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-105939996-A | Dihydropyridone and dihydropyridazinone derivatives as bromodomain inhibitors | 艾伯维公司 | 2016-09-14 | — | — | CN | disclosed |
| CN-102241679-B | Process for the synthesis of 4h-imidazo [1,5-a] [1,4] benzodiazepines, in particular midazolam and salts thereof | ITALIANA SINT SPA | 2014-08-13 | — | — | CN | disclosed |
| US-8557981-B2 | Process for the synthesis of 4H-imidazo [1,5-a] [1,4] benzodiazepines, in particular midazolam and salts thereof | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2013-10-15 | — | — | US | disclosed |
| EP-2397470-B1 | Process for the synthesis of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular midazolam and salts thereof | ITALIANA SINT SPA (IT) | 2013-01-16 | — | — | EP | disclosed |
| EP-2397470-A1 | Process for the synthesis of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular midazolam and salts thereof | F.I.S. Fabbrica Italiana Sintetici S.p.A. (IT) | 2011-12-21 | — | — | EP | disclosed |
| CN-102241679-A | Process for the synthesis of 4h-imidazo [1,5-a] [1,4] benzodiazepines, in particular midazolam and salts thereof | ITALIANA SINT SPA | 2011-11-16 | — | — | CN | disclosed |
| US-20110275799-A1 | PROCESS FOR THE SYNTHESIS OF 4H-IMIDAZO [1,5-a] [1,4] BENZODIAZEPINES, IN PARTICULAR MIDAZOLAM AND SALTS THEREOF | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A (IT) | 2011-11-10 | — | — | US | disclosed |
| US-4368157-A | ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-01-11 | — | — | US | disclosed |
| US-4368159-A | ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-01-11 | — | — | US | disclosed |
| US-4368158-A | ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-01-11 | — | — | US | disclosed |
| US-4349476-A | IMIDAZO/1,5-A//1,4) BENZO-, THIENO-, OR PYRAZOLODIAZEPINES FROM DERIVATIVES OF BENZO-, THIENO- OR PYRAZOLODIAZEPINE | HOFFMANN-LA ROCHE INC. (US) | 1982-09-14 | — | — | US | disclosed |
| US-4349477-A | IMIPAZO/1,5-A//1,4/BENZO-, THIENO- OR PYRAZOLODIAZEPINES FROM 2-DIMORPHOLINOPHOSPHONATES OF BENZO-, THIENO- OR PYRAZOLODIAZEPINES | HOFFMANN-LA ROCHE INC. (US) | 1982-09-14 | — | — | US | disclosed |
| US-4349475-A | IMIDAZO/1,5-A//1,4/BENZO-, THIENO-, OR PYRAZOLODIAZEPINES FROM DERIVATIVES OF BENZOTHIENO-OR PYRAZOLODIAZEPINES | HOFFMANN-LA ROCHE INC. (US) | 1982-09-14 | — | — | US | disclosed |
| US-4347365-A | ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1982-08-31 | — | — | US | disclosed |
| US-4347364-A | INTERMEDIATES THEREFOR | HOFFMANN-LA ROCHE INC. (US) | 1982-08-31 | — | — | US | disclosed |
| US-4307237-A | ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1981-12-22 | — | — | US | disclosed |
| US-4280957-A | Imidazodiazepines and processes therefor | HOFFMANN-LA ROCHE INC. (US) | 1981-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275799-A1 | PROCESS FOR THE SYNTHESIS OF 4H-IMIDAZO [1,5-a] [1,4] BENZODIAZEPINES, IN PARTICULAR MIDAZOLAM AND SALTS THEREOF | CYP3A4, CYP3A5, GABRA5 | GABRA1 5/4885GABRA5 3/4885GABRA2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.