Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13118031 | 0.89 | KDM4E (0.42) | AKR1C2AKR1C1KDM4EASPHKDM8 | |
| SCHEMBL13118051 | 0.83 | AKR1C2 (0.42) | AKR1C2AKR1C1TRPV1KDM5AKDM4C | |
| SCHEMBL14184585 | 0.82 | XDH (0.45) | AKR1C2AKR1C3TRPV1 | |
| SCHEMBL12126160 | 0.82 | KDM4E (0.42) | KDM4EASPHKDM8MAP3K5KDM5A | |
| SCHEMBL13108539 | 0.79 | ALDH1A1 (0.41) | KDM4EASPHKDM8KDM5AKDM5B | |
| SCHEMBL13108535 | 0.75 | KDM4E (0.38) | AKR1C2AKR1C1KDM4EASPHKDM8 | |
| SCHEMBL13108552 | 0.72 | GAA (0.41) | KDM4EASPHKDM8ALDH1A1 | |
| SCHEMBL12126242 | 0.70 | AKR1C2 (0.37) | AKR1C2AKR1C3AKR1C1KDM5AKDM4C | |
| SCHEMBL13004322 | 0.69 | XDH (0.48) | KDM4EASPHKDM8ALDH1A1 | |
| SCHEMBL13004332 | 0.69 | KDM4E (0.41) | AKR1C2AKR1C3TRPV1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816558-B2 | Triarylcarboxylic acid derivative | ASTELLAS PHARMA INC. (JP) | 2010-10-19 | — | — | US | disclosed |
| US-20090018104-A1 | Triarylcarboxylic Acid Derivative | ASTELLAS PHARMA INC. (JP) | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018104-A1 | Triarylcarboxylic Acid Derivative | XDH, NLRP3, UACA | AKR1C2 109/4885AKR1C3 89/4885AKR1C1 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.