Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12789152 | 0.77 | TSHR (0.50) | — | |
| SCHEMBL422198 | 0.77 | TSHR (0.50) | GABRA1GABRB1 | |
| SCHEMBL11574451 | 0.77 | GABRA1 (0.46) | GABRA1GABRB1 | |
| SCHEMBL12868157 | 0.75 | — | — | |
| Ammonia Solution, Strong SCHEMBL5676040 | 0.74 | TSHR (0.47) | GABRA1GABRB1 | |
| Hydrogen Peroxide SCHEMBL11577393 | 0.72 | GABRA1 (0.48) | GABRA1GABRB1 | |
| SCHEMBL11960296 | 0.71 | — | — | |
| SCHEMBL12297348 | 0.71 | FFAR4 (0.34) | — | |
| SCHEMBL12204680 | 0.71 | ESR1 (0.34) | — | |
| SCHEMBL1102398 | 0.70 | TYR (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7807684-B2 | HIV reverse transcriptase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-10-05 | — | — | US | disclosed |
| US-20070021442-A1 | HIV reverse transcriptase inhibitors | MERCK SHARP & DOHME CORP. | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021442-A1 | HIV reverse transcriptase inhibitors | POLRMT, RNGTT, POLR2E | GABRA1 4211/4885GABRB1 4526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.