SCHEMBL1312464

SCHEMBL1312464

O=C(O)[C@@H](O)Cc1c[nH]cn1

nearest known ligand 0.50

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PTPRA P18433 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.41
KDM6B O15054 1/20 0.36
OR51E2 Q9H255 1/20 0.32
CYP3A4 P08684 1/20 0.31
SLC7A5 Q01650 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1312465 1.00 PTPRA (0.50) PTPRASMN1; SMN2KDM6BOR51E2CYP3A4
Water SCHEMBL2000818 0.98 PTPRA (0.49) PTPRASMN1; SMN2KDM6BOR51E2CYP3A4
Water SCHEMBL2000820 0.98 PTPRA (0.49) PTPRASMN1; SMN2KDM6BOR51E2CYP3A4
SCHEMBL7433498 0.85 PTPRA (0.33) PTPRACYP3A4SLC7A5
Imidazole SCHEMBL1241426 0.84 PTPRA (0.41) PTPRASMN1; SMN2
SCHEMBL16452409 0.84 PTPRA (0.34) PTPRA
SCHEMBL8255199 0.84 PTPRA (0.34) PTPRA
SCHEMBL3803098 0.84 PTPRA (0.34) PTPRA
SCHEMBL14640012 0.81 PTPRA (0.33) PTPRA
SCHEMBL13201637 0.81 PTPRA (0.33) PTPRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 151 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109922835-B DCHBS active ester of PEG compound and application thereof 诺和诺德股份有限公司 2023-08-04 CN claimed
US-20220232831-A1 NOVEL NON-CODING HETEROCYCLIC AMINO ACIDS (NCHAA) AND THEIR USE AS HERBICIDES FORTEPHEST LTD. (IL) 2022-07-28 US claimed
CN-107108714-B GLP-1 derivatives and uses thereof 诺和诺德股份有限公司 2022-02-08 CN claimed
CN-113939499-A Novel non-coding heterocyclic amino acids (NCHAA) and their use as herbicides 福提费斯特有限公司 2022-01-14 CN claimed
US-10946074-B2 GLP-1 derivatives and uses thereof NOVO NORDISK A/S (DK) 2021-03-16 US claimed
CN-112300435-A Environment-friendly polyurethane foaming agent and preparation method thereof 宋庆红 2021-02-02 CN claimed
US-10689429-B2 Double-acylated GLP-1 compounds NOVO NORDISK A/S (DK) 2020-06-23 US claimed
US-10392428-B2 GLP-1 derivatives and uses thereof NOVO NORDISK A/S (DK) 2019-08-27 US claimed
EP-3129041-B1 DOUBLE-ACYLATED GLP-1 COMPOUNDS NOVO NORDISK AS (DK) 2019-06-12 EP claimed
US-20190038721-A1 GLP-1 DERIVATIVES AND USES THEREOF NOVO NORDISK A/S (DK) 2019-02-07 US claimed
EP-3016975-A1 DERIVATIVES OF GLP-1 LIKE PEPTIDES, AND USES THEREOF Novo Nordisk A/S (DK) 2016-05-11 EP claimed
EP-3010546-A1 GLP-1 DERIVATIVES AND USES THEREOF Novo Nordisk A/S (DK) 2016-04-27 EP claimed
CN-105451776-A GLP-1 derivatives and uses thereof NOVO NORDISK AS 2016-03-30 CN claimed
CN-105377306-A Glp-1 derivatives and uses thereof NOVO NORDISK AS 2016-03-02 CN claimed
CN-105377884-A Derivatives of GLP-1 like peptides, and uses thereof NOVO NORDISK AS 2016-03-02 CN claimed
WO-2015155151-A1 DOUBLE-ACYLATED GLP-1 COMPOUNDS NOVO NORDISK A/S (DK) 2015-10-15 WO claimed
WO-2015022400-A1 GLP-1 DERIVATIVES, AND USES THEREOF NOVO NORDISK A/S (DK) 2015-02-19 WO claimed
US-20150011462-A1 DERIVATIVES OF GLP-1 LIKE PEPTIDES, AND USES THEREOF NOVO NORDISK A/S (DK) 2015-01-08 US claimed
WO-2015000942-A1 DERIVATIVES OF GLP-1 LIKE PEPTIDES, AND USES THEREOF NOVO NORDISK A/S (DK) 2015-01-08 WO claimed
WO-2014202727-A1 GLP-1 DERIVATIVES AND USES THEREOF NOVO NORDISK A/S (DK) 2014-12-24 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190038721-A1 GLP-1 DERIVATIVES AND USES THEREOF GLP1R, DPP8, DPP7 PTPRA 2276/4885SMN1; SMN2 4259/4885KDM6B 1307/4885
US-20150011462-A1 DERIVATIVES OF GLP-1 LIKE PEPTIDES, AND USES THEREOF GLP1R, GIPR, IAPP PTPRA 3391/4885SMN1; SMN2 1630/4885KDM6B 4189/4885
US-10392428-B2 GLP-1 derivatives and uses thereof GLP1R, GIPR, VIP PTPRA 4271/4885SMN1; SMN2 2317/4885KDM6B 3629/4885
US-20220232831-A1 NOVEL NON-CODING HETEROCYCLIC AMINO ACIDS (NCHAA) AND THEIR USE AS HERBICIDES SLC43A1, NPPA, NAAA PTPRA 2310/4885SMN1; SMN2 3850/4885KDM6B 991/4885
US-10689429-B2 Double-acylated GLP-1 compounds GLP1R, GIPR, GPR119 PTPRA 4536/4885SMN1; SMN2 2152/4885KDM6B 181/4885
US-10946074-B2 GLP-1 derivatives and uses thereof GLP1R, DPP8, DPP7 PTPRA 2276/4885SMN1; SMN2 4259/4885KDM6B 1307/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.