SCHEMBL1313539

SCHEMBL1313539

COc1ccc(Cn2c3ncnc4c(ncn4Cc4ccc(OC)cc4)c-3nc2=O)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.53
SLC29A1 Q99808 1/20 0.49
HDAC1 Q13547 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
ADORA2A P29274 1/20 0.47
FGFR1 P11362 1/20 0.46
FGFR2 P21802 1/20 0.46
FGFR4 P22455 1/20 0.46
FGFR3 P22607 1/20 0.46
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
PDE1B Q01064 3/20 0.43
NR3C1 P04150 2/20 0.43
NSD3 Q9BZ95 1/20 0.42
PDE10A Q9Y233 1/20 0.42
ALDH1A1 P00352 2/20 0.42
KDM4E B2RXH2 1/20 0.42
USP2 O75604 1/20 0.42
POLB P06746 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18199179 0.97 HPGD (0.50) HPGDSLC29A1HDAC1HDAC6ADORA2A
SCHEMBL29208373 0.95 HPGD (0.48) HPGDSLC29A1HDAC1HDAC6ADORA2A
SCHEMBL29208349 0.92 HPGD (0.48) HPGDSLC29A1HDAC1HDAC6ADORA2A
SCHEMBL1312875 0.90 HPGD (0.48) HPGDSLC29A1HDAC1HDAC6ADORA2A
SCHEMBL12112160 0.89 PDE10A (0.48) SLC29A1HDAC6ADORA2AFGFR1FGFR4
SCHEMBL12112213 0.88 PDE10A (0.42) HPGDSLC29A1HDAC1HDAC6ADORA2A
SCHEMBL16123784 0.86 SLC29A1 (0.46) SLC29A1HDAC6ADORA2AFGFR1FGFR4
SCHEMBL13394148 0.85 SLC29A1 (0.47) SLC29A1HDAC6ADORA2AFGFR1FGFR4
SCHEMBL15214749 0.85 ADORA2A (0.47) SLC29A1HDAC6ADORA2AFGFR1FGFR4
SCHEMBL15214751 0.85 PDE10A (0.51) SLC29A1HDAC1HDAC6ADORA2AFGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115201-A1 POTENTIAL THERAPEUTICS FOR FIBROSIS BY BLOCKING THE INCREASE OF A KEY ENZYME TEXAS A & M UNIV SYS (US) 2026-04-30 US claimed
US-12569499-B2 Intravenous formulations of RK-33 NATSAR PHARMACEUTICALS, INC. (US) 2026-03-10 US claimed
EP-4395765-A1 INTRAVENOUS FORMULATIONS OF RK-33 Natsar Pharmaceuticals, Inc. (US) 2024-07-10 EP claimed
US-11976073-B2 Bicyclic amines as CDK2 inhibitors INCYTE CORPORATION (US) 2024-05-07 US claimed
US-20240138263-A1 LIGHT EMITTING ELEMENT AND POLYCYCLIC COMPOUND FOR THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2024-04-25 US claimed
WO-2024081018-A1 POTENTIAL THERAPEUTICS FOR FIBROSIS BY BLOCKING THE INCREASE OF A KEY ENZYME THE TEXAS A&M UNIVERSITY SYSTEM (US) 2024-04-18 WO claimed
CN-116769915-A Marker detection object for breast cancer diagnosis or prognosis evaluation, application thereof, kit and targeted inhibitor 中国医科大学附属第一医院 2023-09-19 CN claimed
US-20230192706-A1 BICYCLIC AMINES AS CDK2 INHIBITORS INCYTE CORPORATION 2023-06-22 US claimed
US-20230183250-A1 BICYCLIC AMINES AS CDK2 INHIBITORS INCYTE CORPORATION 2023-06-15 US claimed
US-20230077636-A1 INTRAVENOUS FORMULATIONS OF RK-33 NATSAR PHARMACEUTICALS, INC. 2023-03-16 US claimed
WO-2023034743-A1 INTRAVENOUS FORMULATIONS OF RK-33 NATSAR PHARMACEUTICALS, INC. (US) 2023-03-09 WO claimed
US-20260115201-A1 POTENTIAL THERAPEUTICS FOR FIBROSIS BY BLOCKING THE INCREASE OF A KEY ENZYME TEXAS A & M UNIV SYS (US) 2026-04-30 US disclosed
WO-2026090160-A2 CD4-TARGETED IL-15 MOLECULES AND METHODS OF USE GILEAD SCIENCES, INC. (US) 2026-04-30 WO disclosed
US-12612395-B2 Rocaglate derivatives and uses thereof TRUSTEES OF BOSTON UNIVERSITY (US) 2026-04-28 US disclosed
US-20260109746-A1 CD4-TARGETED IL-15 MOLECULES AND METHODS OF USE GILEAD SCIENCES INC (US) 2026-04-23 US disclosed
WO-2012122471-A2 COMPOUNDS AND METHODS OF USE IN ABLATIVE RADIOTHERAPY THE JOHNS HOPKINS UNIVERSITY (US) 2012-09-13 WO disclosed
US-20110275588-A1 Fused Diimidazodiazepine Compounds and Methods of Use and Manufacture Thereof HOSMANE, RAMACHANDRA S. 2011-11-10 US disclosed
US-20110275588-A1 Fused Diimidazodiazepine Compounds and Methods of Use and Manufacture Thereof HOSMANE, RAMACHANDRA S. 2011-11-10 US disclosed
US-20110275588-A1 Fused Diimidazodiazepine Compounds and Methods of Use and Manufacture Thereof HOSMANE, RAMACHANDRA S. 2011-11-10 US disclosed
WO-2010039187-A2 FUSED DIIMIDAZODIAZEPINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE THEREOF UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) 2010-04-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12569499-B2 Intravenous formulations of RK-33 DDX3X, DDX39B, HNRNPA3 HPGD 4163/4885SLC29A1 1283/4885HDAC1 1194/4885
US-20230183250-A1 BICYCLIC AMINES AS CDK2 INHIBITORS CDK2, CCNI, CDK1 HPGD 980/4885SLC29A1 1255/4885HDAC1 148/4885
US-20230192706-A1 BICYCLIC AMINES AS CDK2 INHIBITORS CDK2, CCNI, CDK1 HPGD 980/4885SLC29A1 1255/4885HDAC1 148/4885
US-11976073-B2 Bicyclic amines as CDK2 inhibitors CDK2, CCNI, CDK1 HPGD 980/4885SLC29A1 1255/4885HDAC1 148/4885
US-20260115201-A1 POTENTIAL THERAPEUTICS FOR FIBROSIS BY BLOCKING THE INCREASE OF A KEY ENZYME DDX3X, DDX39B, DDX1 HPGD 4065/4885SLC29A1 1577/4885HDAC1 2129/4885
US-12612395-B2 Rocaglate derivatives and uses thereof GLRB, SRR, HCAR3 HPGD 1791/4885SLC29A1 1542/4885HDAC1 1317/4885
US-20110275588-A1 Fused Diimidazodiazepine Compounds and Methods of Use and Manufacture Thereof IKZF3, AADAC, IKBKE HPGD 750/4885SLC29A1 3265/4885HDAC1 51/4885
US-20230077636-A1 INTRAVENOUS FORMULATIONS OF RK-33 IL33, TRIM33, PRKD3 HPGD 2915/4885SLC29A1 935/4885HDAC1 3785/4885
US-20260109746-A1 CD4-TARGETED IL-15 MOLECULES AND METHODS OF USE IL15, IL15RA, CD4 HPGD 2395/4885SLC29A1 2287/4885HDAC1 4145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.