Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136409 | 0.90 | MDM2 (0.44) | CYP2D6CYP3A4MDM2ALDH1A1MEN1 | |
| SCHEMBL13788869 | 0.86 | MDM2 (0.45) | CYP2D6CYP3A4MDM2ALDH1A1MEN1 | |
| SCHEMBL11362057 | 0.73 | ALDH1A1 (0.40) | CYP2D6MDM2ALDH1A1MEN1CYP1A2 | |
| SCHEMBL1948836 | 0.72 | PGR (0.47) | CYP2D6MDM2ALDH1A1MEN1CYP1A2 | |
| SCHEMBL2597754 | 0.72 | ALDH1A1 (0.42) | CYP2D6MDM2ALDH1A1MEN1CYP1A2 | |
| SCHEMBL2599267 | 0.72 | ALDH1A1 (0.42) | CYP2D6MDM2ALDH1A1MEN1CYP1A2 | |
| SCHEMBL2599307 | 0.72 | ALDH1A1 (0.42) | CYP2D6MDM2ALDH1A1MEN1CYP1A2 | |
| SCHEMBL13136413 | 0.69 | ELANE (0.39) | CYP2D6MDM2ALDH1A1MEN1CYP1A2 | |
| SCHEMBL3941349 | 0.68 | ALDH1A1 (0.41) | CYP2D6CYP3A4MDM2ALDH1A1MEN1 | |
| SCHEMBL2597761 | 0.67 | ATM (0.41) | MDM2ALDH1A1MEN1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790832-B2 | Methods for purifying 2-aryl-3,3-bis(hydroxyaryl)phthalimidines | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2010-09-07 | — | — | US | disclosed |
| US-7563817-B2 | Purified 2-aryl-3,3-bis(hydroxyaryl)phthalimidines | SABIC INNOVATIVE PLASTICS IP BV (NL) | 2009-07-21 | — | — | US | disclosed |
| US-7348439-B2 | 2-aryl-3-(aminoaryl)-3-(hydroxyaryl)phthalimidine compounds and methods for making them | GENERAL ELECTRIC COMPANY (US) | 2008-03-25 | — | — | US | disclosed |
| US-20080058497-A1 | METHODS FOR PURIFYING 2-ARYL-3,3-BIS(HYDROXYARYL)PHTHALIMIDINES | GENERAL ELECTRIC COMPANY (US) | 2008-03-06 | — | — | US | disclosed |
| US-20070197761-A1 | 2-ARYL-3-(AMINOARYL)-3-(HYDROXYARYL)PHTHALIMIDINE COMPOUNDS AND METHODS FOR MAKING THEM | GENERAL ELECTRIC COMPANY (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070135612-A1 | Methods for purifying 2-aryl-3,3-bis(hydroxyaryl)phthalimidines | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2007-06-14 | — | — | US | disclosed |
| US-20070123714-A1 | 2-ARYL-3-(AMINOARYL)-3-(HYDROXYARYL)PHTHALIMIDINE COMPOUNDS AND METHODS FOR MAKING THEM | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197761-A1 | 2-ARYL-3-(AMINOARYL)-3-(HYDROXYARYL)PHTHALIMIDINE COMPOUNDS AND METHODS FOR MAKING THEM | AHR, ARNT, AR | CYP2D6 87/4885CYP3A4 91/4885MDM2 83/4885 |
| US-20070123714-A1 | 2-ARYL-3-(AMINOARYL)-3-(HYDROXYARYL)PHTHALIMIDINE COMPOUNDS AND METHODS FOR MAKING THEM | AHR, ARNT, AR | CYP2D6 87/4885CYP3A4 91/4885MDM2 83/4885 |
| US-20070135612-A1 | Methods for purifying 2-aryl-3,3-bis(hydroxyaryl)phthalimidines | AHR, ARSA, CBR1 | CYP2D6 251/4885CYP3A4 230/4885MDM2 278/4885 |
| US-20080058497-A1 | METHODS FOR PURIFYING 2-ARYL-3,3-BIS(HYDROXYARYL)PHTHALIMIDINES | AHR, ARSA, CBR1 | CYP2D6 251/4885CYP3A4 230/4885MDM2 278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.