Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | F9 | P00740 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | CFD | P00746 | 2/20 | 0.33 |
| ▸ | PLG | P00747 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 2/20 | 0.33 |
| ▸ | PLAT | P00750 | 2/20 | 0.33 |
| ▸ | F11 | P03951 | 2/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.33 |
| ▸ | F7 | P08709 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27450326 | 0.85 | TNKS2 (0.43) | TNKS2ALDH1A1TLR8TSHRRAB9A | |
| SCHEMBL12013414 | 0.84 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL334409 | 0.80 | CNR1 (0.41) | TNKS2ALDH1A1TLR8TSHRCNR1 | |
| SCHEMBL1423103 | 0.80 | TNKS2 (0.42) | TNKS2ALDH1A1TLR8TSHRSMN1; SMN2 | |
| SCHEMBL10053298 | 0.79 | L3MBTL1 (0.44) | ALDH1A1L3MBTL1PPARGPPARDPPARA | |
| SCHEMBL334184 | 0.78 | TNKS2 (0.41) | TNKS2ALDH1A1TLR8TSHRSMN1; SMN2 | |
| SCHEMBL28785864 | 0.78 | TNKS2 (0.38) | TNKS2ALDH1A1TLR8TSHRCNR1 | |
| SCHEMBL13150551 | 0.77 | GABRA1 (0.38) | ALDH1A1TSHRRAB9ASMN1; SMN2CNR1 | |
| SCHEMBL26723854 | 0.74 | TACR1 (0.35) | L3MBTL1RAB9ASMN1; SMN2CNR1MEN1 | |
| SCHEMBL1421997 | 0.73 | TNKS2 (0.36) | TNKS2ALDH1A1TLR8TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362054-B2 | Therapeutic substituted lactams | ALLERGAN, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-7803797-B2 | Substituted arylcyclopentenes as therapeutic agents | ALLERGAN, INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-20100168189-A1 | THERAPEUTIC SUBSTITUTED LACTAMS | ALLERGAN, INC. | 2010-07-01 | — | — | US | disclosed |
| US-20090270385-A1 | SUBSTITUTED ARYLCYCLOPENTENES AS THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 2009-10-29 | — | — | US | disclosed |
| WO-2008100809-A1 | GAMMA-LACTAMS FOR THE TREATMENT OF GLAUCOMA OR ELEVATED INTRAOCULAR PRESSURE | ALLERGAN, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270385-A1 | SUBSTITUTED ARYLCYCLOPENTENES AS THERAPEUTIC AGENTS | GBA1, GNAO1, UGT2B7 | TNKS2 3033/4885ALDH1A1 551/4885L3MBTL1 3022/4885 |
| US-20100168189-A1 | THERAPEUTIC SUBSTITUTED LACTAMS | PIGO, GARS1, CLPP | TNKS2 2260/4885ALDH1A1 2303/4885L3MBTL1 3603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.