Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10250706 | 0.93 | MTNR1B (0.47) | ADORA2BADORA2ANPC1RAB9AMEN1 | |
| SCHEMBL13152778 | 0.92 | SMN1; SMN2 (0.43) | ADORA2BADORA2ANPC1RAB9AMEN1 | |
| SCHEMBL13152684 | 0.92 | ALDH1A1 (0.40) | ADORA2BADORA2ANPC1RAB9AMEN1 | |
| SCHEMBL13152223 | 0.91 | NPC1 (0.50) | ADORA2BADORA2ANPC1RAB9AMEN1 | |
| SCHEMBL13152749 | 0.90 | NPC1 (0.39) | ADORA2BADORA2ANPC1RAB9AMEN1 | |
| SCHEMBL13153261 | 0.89 | MTNR1B (0.49) | ADORA2BADORA2ANPC1RAB9AMEN1 | |
| SCHEMBL10097506 | 0.88 | ROCK2 (0.41) | ADORA2BADORA2ANPC1RAB9AMEN1 | |
| SCHEMBL13151937 | 0.87 | PKM (0.42) | ADORA2BADORA2ANPC1RAB9AMEN1 | |
| SCHEMBL13152699 | 0.86 | SMN1; SMN2 (0.42) | NPC1RAB9AMEN1KMT2AMTNR1B | |
| SCHEMBL10254338 | 0.86 | PKM (0.44) | NPC1RAB9AMTNR1BLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |