Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13152321 | 0.94 | MTNR1B (0.47) | MTNR1BNAMPTNPC1DYRK1A | |
| SCHEMBL13151940 | 0.92 | MTNR1B (0.49) | MTNR1BNAMPTADORA2BADORA1ADORA2A | |
| SCHEMBL10254338 | 0.92 | PKM (0.44) | MTNR1BNAMPTKDRNPC1RAB9A | |
| SCHEMBL12950382 | 0.91 | MAPT (0.42) | MTNR1BKDRNPC1RAB9AMEN1 | |
| SCHEMBL13152142 | 0.89 | ADORA2B (0.41) | MTNR1BADORA2BADORA1ADORA2ANPC1 | |
| SCHEMBL13151937 | 0.89 | PKM (0.42) | MTNR1BNAMPTADORA2BADORA1ADORA2A | |
| SCHEMBL10251176 | 0.88 | HSD17B10 (0.44) | MTNR1BNAMPTKDRDYRK1AABCB1 | |
| SCHEMBL13152308 | 0.88 | HSD17B10 (0.42) | MTNR1BNAMPTKDRNPC1RAB9A | |
| SCHEMBL10097331 | 0.88 | FPR2 (0.52) | MTNR1BROCK2NPC1RAB9AMEN1 | |
| SCHEMBL10097495 | 0.87 | ALDH1A1 (0.47) | NAMPTADORA2BADORA1ADORA2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |