SCHEMBL1315890

SCHEMBL1315890

O=C(Nc1cc(-c2ccccc2)ccc1C(=O)O)c1cc(Cl)ccc1O

nearest known ligand 0.67

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ACLY P53396 8/20 0.67
SERPINE1 P05121 2/20 0.61
TMPRSS4 Q9NRS4 1/20 0.60
GRIK1 P39086 3/20 0.60
KCNMA1 Q12791 2/20 0.59
SUCNR1 Q9BXA5 1/20 0.57
HDAC1 Q13547 2/20 0.54
DHFR P00374 1/20 0.54
HNF4A P41235 1/20 0.54
MCL1 Q07820 1/20 0.54
ACMSD Q8TDX5 1/20 0.54
HDAC2 Q92769 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1317521 0.91 ACLY (0.68) ACLYSERPINE1GRIK1KCNMA1SUCNR1
SCHEMBL1318525 0.91 ACLY (0.67) ACLYKCNMA1HDAC1DHFRHNF4A
SCHEMBL13206537 0.87 ACLY (0.59) ACLYKCNMA1SUCNR1HDAC1DHFR
SCHEMBL2270596 0.87 ACLY (0.70) ACLYSERPINE1GRIK1SUCNR1
SCHEMBL27696863 0.86 ACLY (0.62) ACLYSERPINE1GRIK1KCNMA1SUCNR1
SCHEMBL2272453 0.85 ACLY (0.63) ACLYKCNMA1SUCNR1HDAC1DHFR
SCHEMBL1317243 0.85 ACLY (0.56) ACLYKCNMA1HDAC1DHFRHNF4A
SCHEMBL13206145 0.85 ACLY (0.56) ACLYKCNMA1HDAC1DHFRHNF4A
SCHEMBL1316555 0.85 ACLY (0.56) ACLYHDAC1DHFRHNF4AMCL1
SCHEMBL13206516 0.84 ACLY (0.61) ACLYSUCNR1HDAC1DHFRHNF4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102333757-B N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD 2014-11-26 CN disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 ACLY 295/4885SERPINE1 470/4885TMPRSS4 3323/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.