SCHEMBL1316049

SCHEMBL1316049

CC(C)(C)OC(=O)c1ccc(-c2cncc3ccccc23)cc1N

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ PRKCZ Q05513 1/20 0.48
▸ CYP11B1 P15538 12/20 0.47
▸ CYP11B2 P19099 12/20 0.47
▸ CYP2D6 P10635 2/20 0.47
▸ CYP2C9 P11712 2/20 0.47
▸ CYP2B6 P20813 2/20 0.47
▸ CYP2C19 P33261 2/20 0.47
▸ CYP1A2 P05177 1/20 0.47
▸ CYP3A4 P08684 1/20 0.47
▸ WNT1 P04628 1/20 0.46
▸ DYRK1A Q13627 1/20 0.46
▸ MMP9 P14780 2/20 0.43
▸ ERN1 O75460 2/20 0.42
▸ MMP1 P03956 1/20 0.42
▸ PRMT5 O14744 1/20 0.40
▸ WDR77 Q9BQA1 1/20 0.40
▸ SLC22A12 Q96S37 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1315718 0.83 ERN1 (0.52) PRKCZCYP11B1CYP11B2CYP2D6CYP2C9
SCHEMBL12121434 0.82 PRKCZ (0.56) PRKCZCYP11B1CYP11B2CYP2D6CYP2C9
SCHEMBL4212947 0.79 ABCG2 (0.44) CYP11B1CYP11B2CYP2D6CYP2C9CYP2B6
SCHEMBL12117476 0.77 MCL1 (0.46) —
SCHEMBL1320007 0.77 SERPINE1 (0.49) CYP11B1CYP11B2CYP2D6CYP2C9CYP2B6
SCHEMBL1315998 0.76 IKBKB (0.47) —
SCHEMBL1315716 0.75 EDNRB (0.46) —
SCHEMBL10272839 0.73 NAMPT (0.57) PRKCZCYP11B1CYP11B2CYP2D6CYP2C9
SCHEMBL4308602 0.73 CYP11B2 (0.49) PRKCZCYP11B1CYP11B2CYP2D6CYP2C9
SCHEMBL1316109 0.72 AXL (0.43) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 — — US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 — — US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 — — US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 — — US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 PRKCZ 4066/4885CYP11B1 739/4885CYP11B2 833/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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