SCHEMBL1316675

SCHEMBL1316675

CNc1ccc(C(=O)Nc2cc(-c3ccccc3)ccc2C(=O)O)c(O)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACLY P53396 7/20 0.55
HNF4A P41235 2/20 0.52
ACMSD Q8TDX5 2/20 0.52
HDAC1 Q13547 4/20 0.50
GRIK1 P39086 1/20 0.49
PKM P14618 1/20 0.49
KMT2A Q03164 1/20 0.49
HDAC2 Q92769 1/20 0.49
KDM4E B2RXH2 1/20 0.47
APOBEC3A P31941 1/20 0.47
GFER P55789 1/20 0.47
APOBEC3G Q9HC16 1/20 0.47
DHODH Q02127 1/20 0.47
KCNMA1 Q12791 1/20 0.46
TUBB4A P04350 1/20 0.46
TUBB P07437 1/20 0.46
TUBA3C P0DPH7 1/20 0.46
TUBA1B P68363 1/20 0.46
TUBA4A P68366 1/20 0.46
TUBB4B P68371 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12121824 0.88 HDAC1 (0.46) ACLYHNF4AACMSDHDAC1KMT2A
SCHEMBL1320352 0.88 ACMSD (0.68) ACLYHNF4AACMSDHDAC1KMT2A
SCHEMBL1319068 0.85 HDAC1 (0.46) ACLYHNF4AACMSDHDAC1KMT2A
SCHEMBL1316633 0.85 ACLY (0.57) ACLYHNF4AACMSDHDAC1HDAC2
SCHEMBL2272453 0.84 ACLY (0.63) ACLYHNF4AACMSDHDAC1KMT2A
SCHEMBL13206516 0.83 ACLY (0.61) ACLYHNF4AACMSDHDAC1HDAC2
SCHEMBL1317521 0.82 ACLY (0.68) ACLYHNF4AACMSDGRIK1KCNMA1
SCHEMBL1317238 0.81 ACLY (0.60) ACLYHNF4AACMSDHDAC1PKM
SCHEMBL1317676 0.81 ACLY (0.54) ACLYHNF4AACMSDHDAC1HDAC2
SCHEMBL1318525 0.81 ACLY (0.67) ACLYHNF4AACMSDHDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102333757-B N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD 2014-11-26 CN disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
CN-102333757-A N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD 2012-01-25 CN disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed
WO-2010087430-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF 富山化学工業株式会社 (JP) 2010-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 ACLY 295/4885HNF4A 1073/4885ACMSD 74/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.