Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyridostigmine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 11/20 | 1.00 |
| ▸ | BCHE | P06276 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | GLA | P06280 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NNMT | P40261 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridostigmine SCHEMBL29356532 | 1.00 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL29353353 | 0.98 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL41147 | 0.98 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL6536137 | 0.98 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL5791280 | 0.98 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL2761401 | 0.98 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL27511002 | 0.97 | ACHE (0.94) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL4431136 | 0.97 | ACHE (0.94) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL4301247 | 0.97 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL19971970 | 0.92 | ACHE (0.85) | ACHEBCHELMNAGLATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 15388 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-122091739-A | Dynamic response type electrolyte and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| US-12623985-B2 | Selective terminal CH alumination of saturated hydrocarbons | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2026-05-12 | — | — | US | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| EP-4106071-B1 | ELECTROLYTE FOR LITHIUM-SULFUR SECONDARY BATTERY AND LITHIUM-SULFUR SECONDARY BATTERY COMPRISING SAME | LG ENERGY SOLUTION LTD (KR) | 2026-04-29 | — | — | EP | claimed |
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| US-20260097063-A1 | ANTI-C5 ANTIBODY/C5 IRNA DOSING REGIMENS FOR TREATING C5-ASSOCIATED DISEASES | REGENERON PHARMA (US) | 2026-04-09 | — | — | US | claimed |
| CN-121584026-A | Ion polarization enhancement type local high-concentration electrolyte and application thereof in lithium ion battery | 国网湖南省电力有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-12527777-B2 | Sustained release pyridostigmine compositions | VIANEX S.A. (GR) | 2026-01-20 | — | — | US | claimed |
| US-12512514-B2 | Electrolyte solution for lithium-sulfur secondary battery and lithium-sulfur secondary battery comprising same | LG ENERGY SOLUTION, LTD. (KR) | 2025-12-30 | — | — | US | claimed |
| US-RE30633-E | DIURETICS | A. CHRISTIAENS SOCIETE ANONYME (BE) | 1981-06-02 | — | — | US | claimed |
| US-4218457-A | ANTICANCER ACTIVITY AND IMMUNOSTIMULATING ACTIVITY | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-08-19 | — | — | US | claimed |
| EP-0013115-A1 | Herbicidal synergetic composition containing a pyridine N-oxide and a triazinone and a method for controlling weeds therewith | UNIROYAL, INC. (US) | 1980-07-09 | — | — | EP | claimed |
| US-4207310-A | BACTERICIDES, FUNGICIDES, VIRICIDES | TENNECO CHEMICALS, INC. (US) | 1980-06-10 | — | — | US | claimed |
| US-4184844-A | Storage stable indoaniline and indophenol dye solutions, a process for producing the same and hair dye compositions containing the same | L'OREAL (FR) | 1980-01-22 | — | — | US | claimed |
| US-4154834-A | HETEROCYCLIC-(THIO)ALKYLAMINO SUBSTITUTED-4-PYRIMIDONE OR -THIONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-15 | — | — | US | claimed |
| US-4129517-A | PERGLUTARIC ACID | STERLING DRUG INC. (US) | 1978-12-12 | — | — | US | claimed |
| US-4000047-A | PYRIDINE OR QUINOLINE COMPOUND BRIGHTENERS | LEA-RONAL, INC. (US) | 1976-12-28 | — | — | US | claimed |
| US-3960934-A | METAL HALIDE CATALYST | ROHM GMBH (DT) | 1976-06-01 | — | — | US | claimed |
| US-3931205-A | ANTIRHEUMATIC, ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JA) | 1976-01-06 | — | — | US | claimed |