Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyridostigmine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 12/20 | 0.94 |
| ▸ | BCHE | P06276 | 6/20 | 0.94 |
| ▸ | LMNA | P02545 | 4/20 | 0.94 |
| ▸ | GLA | P06280 | 2/20 | 0.94 |
| ▸ | TSHR | P16473 | 1/20 | 0.94 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.94 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NNMT | P40261 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridostigmine SCHEMBL1317 | 0.97 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL29356532 | 0.97 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL29353353 | 0.95 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL2761401 | 0.95 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL5791280 | 0.95 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL41147 | 0.95 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL6536137 | 0.95 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL27511002 | 0.94 | ACHE (0.94) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL4301247 | 0.94 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL19971970 | 0.89 | ACHE (0.85) | ACHEBCHELMNAGLATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264401-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | ASTRAZENECA AB (SE) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264401-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | CYP2S1, HSD11B1, HSD3B1 | ACHE 3645/4885BCHE 1411/4885LMNA 4185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.