Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyridostigmine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 11/20 | 1.00 |
| ▸ | BCHE | P06276 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | GLA | P06280 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.97 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NNMT | P40261 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridostigmine SCHEMBL29353353 | 1.00 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL4301247 | 0.98 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL1317 | 0.98 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL29356532 | 0.98 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL2761401 | 0.97 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL6536137 | 0.97 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL5791280 | 0.97 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL4431136 | 0.95 | ACHE (0.94) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL27511002 | 0.95 | ACHE (0.94) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL19971970 | 0.91 | ACHE (0.85) | ACHEBCHELMNAGLATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3066 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-12527777-B2 | Sustained release pyridostigmine compositions | VIANEX S.A. (GR) | 2026-01-20 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| EP-4566590-A1 | TASTE-MASKING MICROSPHERE, PREPARATION PROCESS THEREFOR, AND USE THEREOF | Harbin Kanon Pharmaceutical Co., Ltd (CN) | 2025-06-11 | — | — | EP | claimed |
| US-12257371-B2 | SiOx barrier for pharmaceutical package and coating process | SIO2 MEDICAL PRODUCTS, LLC (US) | 2025-03-25 | — | — | US | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| WO-2024254056-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | CATALENT ONTARIO LIMITED (CA) | 2024-12-12 | — | — | WO | claimed |
| WO-2024249914-A1 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING DYSTONIA | DUKE UNIVERSITY (US) | 2024-12-05 | — | — | WO | claimed |
| US-20240335376-A1 | GASTRORETENTIVE DOSAGE FORMS FOR SUSTAINED DRUG DELIVERY | AMNEAL COMPLEX PRODUCTS RESEARCH LLC (US) | 2024-10-10 | — | — | US | claimed |
| WO-1999009973-A1 | PHARMACOLOGIC DRUG COMBINATION IN VAGAL-INDUCED ASYSTOLE | EMORY UNIVERSITY (US) | 1999-03-04 | — | — | WO | claimed |
| WO-1999009971-A1 | PHARMACOLOGIC DRUG COMBINATION IN VAGAL-INDUCED ASYSTOLE | EMORY UNIVERSITY (US) | 1999-03-04 | — | — | WO | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| US-5688510-A | POWDER, MACROLOLECULAR ADDITIVE | NIPPON SHINYAKU CO. LTD. (JP) | 1997-11-18 | — | — | US | claimed |
| CN-1143502-A | Medicine for curing diseases and prolonging life | WU XINGUANG (CN) | 1997-02-26 | — | — | CN | claimed |
| EP-0729748-A1 | PROCESS FOR PRODUCING STABLE MEDICINAL COMPOSITION, AND PHARMACEUTICAL PREPARATION | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1996-09-04 | — | — | EP | claimed |
| US-5430030-A | Nerve gas antidote | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1995-07-04 | — | — | US | claimed |
| US-5298504-A | Pyridostigmine, diazepam orclonazepam and arnepal, sycotrol, caramiphen or benactyzine | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1994-03-29 | — | — | US | claimed |
| EP-0140434-A2 | Pharmaceutical composition with systemic anticholineesterasic, agonistic-cholinergic and antimuscarinic activity | PRODOTTI FORMENTI S.r.l. (IT) | 1985-05-08 | — | — | EP | claimed |