Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyridostigmine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 11/20 | 0.97 |
| ▸ | BCHE | P06276 | 6/20 | 0.97 |
| ▸ | LMNA | P02545 | 4/20 | 0.97 |
| ▸ | GLA | P06280 | 2/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.97 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NNMT | P40261 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridostigmine SCHEMBL29356532 | 0.98 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL1317 | 0.98 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL29353353 | 0.97 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL41147 | 0.97 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL6536137 | 0.97 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL5791280 | 0.97 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL27511002 | 0.95 | ACHE (0.94) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL4431136 | 0.95 | ACHE (0.94) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL4301247 | 0.95 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL19971970 | 0.91 | ACHE (0.85) | ACHEBCHELMNAGLATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104244968-A | PH20 polypeptide variants, formulations, and uses thereof | HALOZYME INC | 2014-12-24 | — | — | CN | claimed |
| WO-2023168305-A1 | VIRAL PARTICLES WITH MEMBRANE-BOUND HYALURONIDASE | EXUMA BIOTECH CORP. (US) | 2023-09-07 | — | — | WO | disclosed |
| US-10702452-B2 | Packaging system and methods of alerting a practitioner | BAXTER INTERNATIONAL INC. (US) | 2020-07-07 | — | — | US | disclosed |
| US-20200163832-A1 | PACKAGING SYSTEM AND METHODS OF ALERTING PRACTITIONER | BAXTER HEALTHCARE SA (CH) | 2020-05-28 | — | — | US | disclosed |
| US-20200163833-A1 | Packaging System and Methods of Alerting a Practitioner | BAXTER INTERNATIONAL INC. | 2020-05-28 | — | — | US | disclosed |
| CN-104244968-B | PH20 polypeptide variants, formulation and its application | 哈洛齐梅公司 | 2017-07-25 | — | — | CN | disclosed |
| US-9463138-B2 | Packaging system | BAXTER INTERNATIONAL INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-20150144586-A1 | Packaging System and Methods of Alerting a Practitioner | BAXTER INTERNATIONAL INC. | 2015-05-28 | — | — | US | disclosed |
| CN-104244968-A | PH20 polypeptide variants, formulations, and uses thereof | HALOZYME INC | 2014-12-24 | — | — | CN | disclosed |
| US-20130334165-A1 | PACKAGING SYSTEM AND METHODS OF ALERTING A PRACTITIONER | BAXTER HEALTHCARE SA (CH) | 2013-12-19 | — | — | US | disclosed |
| US-20100326868-A1 | Packaging System | BAXTER INTERNATIONAL INC. (US) | 2010-12-30 | — | — | US | disclosed |
| EP-2003064-B1 | Packaging system | BAXTER INT (US) | 2010-07-07 | — | — | EP | disclosed |
| EP-2014570-A1 | Packaging system and method of use | BAXTER INTERNATIONAL INC. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2008153580-A1 | PACKAGING SYSTEM AND METHOD OF USE | BAXTER INTERNATIONAL INC. (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008153581-A1 | PACKAGING SYSTEM AND METHOD OF ALERTING A PRACTITIONER | BAXTER INTERNATIONAL INC. (US) | 2008-12-18 | — | — | WO | disclosed |
| US-20080308444-A1 | PACKAGING SYSTEM AND METHOD OF ALERTING A PRACTITIONER | BAXTER INTERNATIONAL INC. (US) | 2008-12-18 | — | — | US | disclosed |
| US-20080308443-A1 | PACKAGING SYSTEM AND METHOD OF USE | BAXTER INTERNATIONAL INC. (US) | 2008-12-18 | — | — | US | disclosed |
| EP-2003064-A1 | Packaging system and method of alerting a practitioner | BAXTER INTERNATIONAL INC. (US) | 2008-12-17 | — | — | EP | disclosed |