Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyridostigmine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 11/20 | 0.97 |
| ▸ | BCHE | P06276 | 6/20 | 0.97 |
| ▸ | LMNA | P02545 | 4/20 | 0.97 |
| ▸ | GLA | P06280 | 2/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.94 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.94 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NNMT | P40261 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridostigmine SCHEMBL41147 | 0.98 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL29353353 | 0.98 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL1317 | 0.97 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL29356532 | 0.97 | ACHE (1.00) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL2761401 | 0.95 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL6536137 | 0.95 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL5791280 | 0.95 | ACHE (0.97) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL4431136 | 0.94 | ACHE (0.94) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL27511002 | 0.94 | ACHE (0.94) | ACHEBCHELMNAGLATSHR | |
| Pyridostigmine SCHEMBL19971970 | 0.89 | ACHE (0.85) | ACHEBCHELMNAGLATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390493-B1 | ANTISENSE OLIGONUCLEOTIDE AGAINST HUMAN ACETYLCHOLINESTERASE ISOFORM R (ACHE-R) AND USES THEREOF | YISSUM RES DEV CO (IL) | 2012-11-07 | — | — | EP | disclosed |
| US-20090281165-A1 | Antisense oligonucleotide against human acetylcholinesterase (AChE) and uses thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY | 2009-11-12 | — | — | US | disclosed |
| US-7456154-B2 | Antisense oligonucleotide against human acetylcholinesterase (AChE) and uses thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2008-11-25 | — | — | US | disclosed |
| US-20060178333-A1 | Antisense oligonucleotide against human acetylcholinesterase (AChE) and uses thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM | 2006-08-10 | — | — | US | disclosed |
| US-7074915-B2 | Antisense oligonucleotide against human acetylcholinesterase (AChE) and uses thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2006-07-11 | — | — | US | disclosed |
| EP-1390493-A1 | ANTISENSE OLIGONUCLEOTIDE AGAINST HUMAN ACETYLCHOLINESTERASE (ACHE) AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-25 | — | — | EP | disclosed |
| WO-2003002739-A1 | ANTISENSE OLIGONUCLEOTIDE AGAINST HUMAN ACETYLCHOLINESTERASE (ACHE) AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2003-01-09 | — | — | WO | disclosed |
| EP-0140434-A2 | Pharmaceutical composition with systemic anticholineesterasic, agonistic-cholinergic and antimuscarinic activity | PRODOTTI FORMENTI S.r.l. (IT) | 1985-05-08 | — | — | EP | disclosed |