SCHEMBL1317606

SCHEMBL1317606

COc1cccc(-c2ccc(C(=O)O)c(NC(=O)c3cc(N4CCCCC4)ccc3O)c2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 7/20 0.48
JMJD7 P0C870 1/20 0.47
NR4A1 P22736 1/20 0.47
NR4A2 P43354 1/20 0.47
NR4A3 Q92570 1/20 0.47
NR1H4 Q96RI1 1/20 0.47
KEAP1 Q14145 1/20 0.47
NFE2L2 Q16236 1/20 0.47
MAPT P10636 3/20 0.47
ALDH1A1 P00352 2/20 0.47
QSOX1 O00391 1/20 0.47
NPC1 O15118 1/20 0.47
LMNA P02545 1/20 0.47
PKM P14618 1/20 0.47
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HDAC2 Q92769 1/20 0.45
RXFP1 Q9HBX9 1/20 0.44
ACLY P53396 1/20 0.44
GFER P55789 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1317157 0.92 KEAP1 (0.54) DHODHNR4A1KEAP1NFE2L2MAPT
SCHEMBL1316558 0.91 MEN1 (0.52) DHODHMAPTALDH1A1LMNASMN1; SMN2
SCHEMBL1315669 0.88 ACLY (0.49) DHODHHDAC2ACLYF10HDAC1
SCHEMBL1317580 0.88 MCL1 (0.45) DHODHMAPTALDH1A1NPC1RAB9A
Hydrochloric Acid SCHEMBL1316485 0.87 ACLY (0.48) DHODHHDAC2ACLYF10HDAC1
Hydrochloric Acid SCHEMBL1316255 0.87 ACLY (0.48) DHODHHDAC2ACLYF10HDAC1
SCHEMBL1315963 0.86 MAPT (0.46) DHODHMAPTNPC1LMNARAB9A
SCHEMBL1317247 0.84 MCL1 (0.48) DHODHKEAP1NFE2L2MAPTALDH1A1
SCHEMBL12117573 0.84 RXFP1 (0.50) DHODHKEAP1NFE2L2MAPTNPC1
Hydrochloric Acid SCHEMBL1316818 0.84 ACLY (0.49) HDAC2ACLYHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
CN-102333757-A N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD 2012-01-25 CN disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 DHODH 2784/4885JMJD7 1830/4885NR4A1 804/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.