Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2925046 | 0.91 | MAPT (0.39) | LMNAEGLN1ARMRGPRX4CTSB | |
| SCHEMBL2931417 | 0.82 | MAPT (0.39) | LMNAMETAP2MAPT | |
| SCHEMBL14628462 | 0.78 | CA2 (0.37) | LMNAPBRM1CA12CA1CA2 | |
| SCHEMBL2924883 | 0.75 | MAPT (0.44) | LMNAPBRM1MAPK1FABP3FABP4 | |
| SCHEMBL2927954 | 0.71 | MAPT (0.39) | EGLN1PBRM1MAPT | |
| SCHEMBL1115893 | 0.70 | MAPT (0.42) | LMNAPBRM1FABP3FABP4MAPT | |
| SCHEMBL13176993 | 0.70 | P2RX7 (0.42) | LMNAARHIF1AMAPT | |
| SCHEMBL13989934 | 0.69 | MEN1 (0.45) | LMNAPBRM1MAPK1CA12CA1 | |
| SCHEMBL15143413 | 0.68 | PTPRG (0.51) | ARMRGPRX4PPARGPBRM1CA12 | |
| SCHEMBL13177150 | 0.68 | PBRM1 (0.47) | LMNAARPBRM1HIF1AFABP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910314-B1 | BENZIMIDAZOLE DERIVATIVES FOR TREATMENT OF INFLAMMATORY DISEASES | NOVARTIS AG (CH) | 2010-09-15 | — | — | EP | disclosed |