Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 17/20 | 0.42 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927954 | 0.91 | MAPT (0.39) | P2RX7MAPTKMT2A | |
| SCHEMBL13989967 | 0.89 | P2RX7 (0.42) | P2RX7MEN1MAPTKMT2A | |
| SCHEMBL2925195 | 0.84 | NPC1 (0.40) | P2RX7MAPTKMT2A | |
| SCHEMBL2932570 | 0.78 | MAPT (0.42) | MEN1LMNAMAPTKMT2A | |
| SCHEMBL13989934 | 0.76 | MEN1 (0.45) | MEN1LMNAMAPTKMT2A | |
| SCHEMBL14628462 | 0.75 | CA2 (0.37) | MEN1LMNAKMT2A | |
| SCHEMBL2925046 | 0.71 | MAPT (0.39) | P2RX7MEN1LMNAARMAPT | |
| SCHEMBL13176992 | 0.70 | LMNA (0.38) | LMNAARMAPTHIF1A | |
| SCHEMBL2931581 | 0.69 | POLB (0.55) | MT-CO2MEN1USP2LMNATTR | |
| SCHEMBL1115893 | 0.69 | MAPT (0.42) | MEN1LMNAMAPTKMT2ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910314-B1 | BENZIMIDAZOLE DERIVATIVES FOR TREATMENT OF INFLAMMATORY DISEASES | NOVARTIS AG (CH) | 2010-09-15 | — | — | EP | disclosed |