Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.37 |
| ▸ | CA1 | P00915 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.33 |
| ▸ | FABP3 | P05413 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13989934 | 0.91 | MEN1 (0.45) | CA2CA1LMNAKDM4EMEN1 | |
| SCHEMBL2932570 | 0.80 | MAPT (0.42) | LMNAKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL13176992 | 0.78 | LMNA (0.38) | CA2CA1LMNAPBRM1CA9 | |
| SCHEMBL2927954 | 0.77 | MAPT (0.39) | ALDH1A1KMT2APBRM1CXCR2 | |
| SCHEMBL13176993 | 0.75 | P2RX7 (0.42) | LMNAMEN1KMT2A | |
| SCHEMBL1115893 | 0.73 | MAPT (0.42) | LMNAKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL13989967 | 0.71 | P2RX7 (0.42) | MEN1ALDH1A1KMT2AFABP3FABP4 | |
| SCHEMBL2924883 | 0.71 | MAPT (0.44) | LMNAMEN1ALDH1A1KMT2APBRM1 | |
| SCHEMBL2931556 | 0.69 | MAPT (0.39) | MEN1KMT2AFABP3FABP4POLB | |
| SCHEMBL13177150 | 0.69 | PBRM1 (0.47) | LMNAMEN1ALDH1A1KMT2APBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007009774-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATMENT OF INFLAMMATORY DISEASES | NOVARTIS AG (CH) | 2007-01-25 | — | — | WO | disclosed |