Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3696017 | 0.76 | F10 (0.41) | SMN1; SMN2ALDH1A1TSHRL3MBTL1CYP3A4 | |
| SCHEMBL13498470 | 0.74 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1TSHRNPSR1RAB9A | |
| SCHEMBL13791587 | 0.74 | SIGMAR1 (0.72) | SMN1; SMN2ALDH1A1TSHRNPSR1RAB9A | |
| Hydrochloric Acid SCHEMBL11194141 | 0.73 | LMNA (0.51) | SMN1; SMN2ALDH1A1TSHRRAB9ANPC1 | |
| SCHEMBL12449601 | 0.72 | SIGMAR1 (0.58) | SMN1; SMN2ALDH1A1NPSR1RAB9ANPC1 | |
| SCHEMBL31525392 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1NPSR1L3MBTL1LMNA | |
| SCHEMBL3435840 | 0.72 | KIF11 (0.46) | SMN1; SMN2ALDH1A1CYP2C9RAB9ANPC1 | |
| SCHEMBL8705771 | 0.72 | KIF11 (0.46) | SMN1; SMN2ALDH1A1TSHRRAB9ANPC1 | |
| SCHEMBL5591935 | 0.71 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1TSHRRAB9ANPC1 | |
| SCHEMBL11937211 | 0.71 | ALDH1A1 (0.59) | SMN1; SMN2ALDH1A1TSHRNPSR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | disclosed |