Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.85 |
| ▸ | MAPT | P10636 | 7/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | NPY2R | P49146 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | PRNP | P04156 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13186477 | 0.89 | MEN1 (0.74) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL13186789 | 0.88 | MEN1 (0.73) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL13186458 | 0.85 | CYP1A2 (0.73) | MEN1KMT2AMAPTLMNANPSR1 | |
| SCHEMBL13186475 | 0.81 | L3MBTL1 (0.65) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL15919823 | 0.80 | KDM4E (1.00) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL6849929 | 0.79 | CA2 (0.79) | MAPTLMNAALDH1A1 | |
| SCHEMBL13186474 | 0.78 | MAPT (0.60) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL29484246 | 0.76 | RAB9A (0.86) | MEN1KMT2AMAPTKDM4ENPSR1 | |
| SCHEMBL2228522 | 0.76 | RAB9A (0.86) | MEN1KMT2AMAPTKDM4ENPSR1 | |
| SCHEMBL13186485 | 0.76 | CYP1A2 (0.73) | MEN1KMT2AMAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9198914-B2 | Methods and compositions for modulating RAD51 and homologous recombination | THE UNIVERSITY OF CHICAGO (US) | 2015-12-01 | — | — | US | disclosed |
| US-20140142103-A1 | Methods and Compositions for Modulating Rad51 and Homologous Recombination | THE UNIVERSITY OF CHICAGO (US) | 2014-05-22 | — | — | US | disclosed |
| US-20100248371-A1 | METHODS AND COMPOSITIONS FOR MODULATING RAD51 AND HOMOLOGOUS RECOMBINATION | UNIVERSITY OF CHICAGO (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142103-A1 | Methods and Compositions for Modulating Rad51 and Homologous Recombination | RAD51, MRE11, RAD50 | MEN1 2194/4885KMT2A 1412/4885MAPT 3907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.