Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | RAF1 | P04049 | 3/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | GCK | P35557 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234580 | 0.87 | RAF1 (0.72) | FLT3MAPK13MAPK14RAF1RIPK2 | |
| SCHEMBL13200115 | 0.82 | LMNA (0.54) | FLT3LMNAMAPTMAPK13MAPK14 | |
| SCHEMBL13200145 | 0.82 | RAF1 (0.53) | FLT3MAPK13MAPK14RAF1RIPK2 | |
| SCHEMBL2949523 | 0.82 | RAF1 (0.70) | FLT3MAPK13MAPK14RAF1RIPK2 | |
| SCHEMBL13200112 | 0.77 | ALDH1A1 (0.54) | FLT3LMNAMAPK14SMN1; SMN2NPC1 | |
| SCHEMBL13234659 | 0.77 | RAF1 (0.71) | FLT3MAPK13MAPK14RAF1RIPK2 | |
| SCHEMBL13234582 | 0.76 | MAPK14 (0.73) | FLT3MAPK13MAPK14RAF1RIPK2 | |
| SCHEMBL13200648 | 0.76 | GRM5 (0.59) | FLT3LMNAMAPTSMN1; SMN2RAF1 | |
| SCHEMBL23657475 | 0.74 | SMN1; SMN2 (0.64) | FLT3LMNAMAPTSMN1; SMN2RAF1 | |
| SCHEMBL17675367 | 0.74 | SMN1; SMN2 (0.64) | FLT3LMNAMAPTMAPK14SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |