Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | APP | P05067 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.55 |
| ▸ | SCD | O00767 | 1/20 | 0.54 |
| ▸ | WNT3A | P56704 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28268613 | 0.88 | RAB9A (0.75) | RAB9ANPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL2945639 | 0.84 | GBA1 (0.65) | RAB9ANPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL13200859 | 0.81 | ELOVL1 (0.67) | ALDH1A1KMT2AMEN1APPELOVL1 | |
| SCHEMBL24804672 | 0.81 | MAPK1 (0.62) | RAB9ANPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL2960671 | 0.81 | SMN1; SMN2 (0.65) | RAB9ANPC1ALDH1A1MAPK10SMN1; SMN2 | |
| SCHEMBL6176932 | 0.80 | ALOX5 (0.52) | RAB9ANPC1KMT2AMEN1LMNA | |
| SCHEMBL9366585 | 0.78 | RORC (0.51) | RAB9ANPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL14757279 | 0.78 | GCK (0.71) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13200871 | 0.77 | CSNK1D (0.77) | RAB9ANPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL14757204 | 0.76 | NPC1 (1.00) | RAB9ANPC1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |