Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 3/20 | 0.61 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.59 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | PRKCI | P41743 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5583624 | 0.87 | EGLN2 (0.54) | ATREGLN2FTOMEN1KMT2A | |
| SCHEMBL5583780 | 0.87 | PNLIP (0.63) | KMT2AHPGDLMNATP53MAPT | |
| SCHEMBL18027788 | 0.85 | KDM4E (0.73) | EGLN2FTOKDM4EHTTLMNA | |
| SCHEMBL14284354 | 0.85 | TLR7 (0.67) | EGLN2FTOKDM4EHTTLMNA | |
| SCHEMBL18993449 | 0.85 | CSF1R (0.53) | ATREGLN2FTOKDM4EPRKCI | |
| SCHEMBL14284353 | 0.82 | GRM4 (0.73) | MEN1KMT2AHTTLMNAALDH1A1 | |
| SCHEMBL259103 | 0.82 | ELANE (0.58) | MEN1KMT2AKDM4ELMNATP53 | |
| SCHEMBL18010076 | 0.82 | CSF1R (0.50) | ATREGLN2FTOKDM4EPRKCI | |
| SCHEMBL5936350 | 0.81 | HTT (0.60) | ATRMEN1KMT2AKDM4EHPGD | |
| SCHEMBL7974510 | 0.81 | ATR (0.59) | ATRMEN1KMT2AKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |