Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320621 | 0.89 | POLB (0.60) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL13201300 | 0.84 | LMNA (0.53) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL2969347 | 0.84 | LMNA (0.53) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL2969335 | 0.84 | ALDH1A1 (0.58) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8319711 | 0.84 | ALDH1A1 (0.58) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8320723 | 0.84 | PSEN1 (0.43) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL2964063 | 0.84 | PSEN1 (0.43) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL2953994 | 0.84 | ACHE (0.54) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8320192 | 0.83 | ALDH1A1 (0.48) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL2958796 | 0.83 | ALDH1A1 (0.48) | POLBKMT2AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |