Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2969347 | 1.00 | LMNA (0.53) | LMNAALDH1A1KDM4ETP53MEN1 | |
| SCHEMBL13201342 | 0.91 | MMP2 (0.52) | LMNAALDH1A1KDM4ETP53MEN1 | |
| SCHEMBL2961185 | 0.90 | ATM (0.51) | LMNAALDH1A1KDM4ETP53MEN1 | |
| SCHEMBL8319712 | 0.90 | ATM (0.51) | LMNAALDH1A1KDM4ETP53MEN1 | |
| SCHEMBL8319435 | 0.89 | MMP2 (0.48) | LMNAALDH1A1HTTATMCA12 | |
| SCHEMBL8327363 | 0.86 | MMP2 (0.48) | ALDH1A1L3MBTL1CA12CA1CA2 | |
| SCHEMBL2960166 | 0.86 | HSD17B10 (0.46) | LMNAALDH1A1MEN1MAPTHTT | |
| SCHEMBL8319058 | 0.86 | HSD17B10 (0.46) | LMNAALDH1A1MEN1MAPTHTT | |
| SCHEMBL8328598 | 0.85 | ALDH1A1 (0.51) | LMNAALDH1A1KDM4ETP53MEN1 | |
| SCHEMBL3162410 | 0.85 | LMNA (0.50) | LMNAALDH1A1KDM4ETP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |