Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201289 | 0.89 | POLB (0.62) | POLBNPC1KMT2AMEN1USP2 | |
| SCHEMBL8324754 | 0.86 | MMP2 (0.48) | POLBMMP2MMP9MMP12 | |
| SCHEMBL2963202 | 0.86 | MMP2 (0.48) | POLBMMP2MMP9MMP12 | |
| SCHEMBL13201315 | 0.85 | MMP2 (0.46) | MMP2MMP9MMP12 | |
| SCHEMBL13201342 | 0.84 | MMP2 (0.52) | KMT2AMEN1ALDH1A1LMNAMMP2 | |
| SCHEMBL8319573 | 0.84 | MMP2 (0.44) | POLBKMT2AALDH1A1LMNAMMP2 | |
| SCHEMBL8319091 | 0.84 | MMP9 (0.46) | POLBMMP2MMP9MMP12 | |
| SCHEMBL13201339 | 0.84 | MMP2 (0.46) | POLBALDH1A1MMP2MMP9MMP12 | |
| SCHEMBL8324756 | 0.84 | MMP2 (0.46) | POLBALDH1A1MMP2MMP9MMP12 | |
| SCHEMBL8319548 | 0.83 | ACHE (0.53) | KMT2AMEN1ALDH1A1LMNAMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| WO-2004060874-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |