Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 7/20 | 0.52 |
| ▸ | MMP3 | P08254 | 5/20 | 0.52 |
| ▸ | MMP2 | P08253 | 9/20 | 0.49 |
| ▸ | MMP9 | P14780 | 9/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 5/20 | 0.44 |
| ▸ | MMP12 | P39900 | 4/20 | 0.44 |
| ▸ | MMP14 | P50281 | 3/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326140 | 0.98 | PSEN1 (0.52) | MMP8MMP3MMP2MMP9PSEN1 | |
| SCHEMBL8320651 | 0.90 | MMP9 (0.62) | MMP8MMP3MMP2MMP9MMP1 | |
| SCHEMBL13480199 | 0.89 | MMP2 (0.49) | MMP8MMP3MMP2MMP9MMP1 | |
| SCHEMBL16298354 | 0.89 | MMP2 (0.49) | MMP8MMP3MMP2MMP9MMP1 | |
| SCHEMBL8325151 | 0.87 | MMP9 (0.62) | MMP8MMP3MMP2MMP9MMP1 | |
| SCHEMBL8319047 | 0.87 | PSEN1 (0.52) | MMP8MMP3PSEN1PSEN2APH1B | |
| SCHEMBL13201315 | 0.86 | MMP2 (0.46) | MMP3MMP2MMP9MMP1MMP12 | |
| SCHEMBL13201328 | 0.86 | CA9 (0.52) | MMP8MMP3MMP2MMP9ACHE | |
| SCHEMBL8328120 | 0.85 | PSEN1 (0.55) | MMP8MMP3PSEN1PSEN2APH1B | |
| SCHEMBL8319091 | 0.85 | MMP9 (0.46) | MMP8MMP3MMP2MMP9PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| WO-2004060874-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |