Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 11/20 | 0.62 |
| ▸ | MMP2 | P08253 | 10/20 | 0.62 |
| ▸ | MMP8 | P22894 | 4/20 | 0.54 |
| ▸ | MMP3 | P08254 | 4/20 | 0.54 |
| ▸ | MMP12 | P39900 | 3/20 | 0.54 |
| ▸ | MMP1 | P03956 | 3/20 | 0.54 |
| ▸ | MMP14 | P50281 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325151 | 0.98 | MMP9 (0.62) | MMP9MMP2MMP8MMP3MMP12 | |
| SCHEMBL13201342 | 0.91 | MMP2 (0.52) | MMP9MMP2MMP8MMP3MMP12 | |
| SCHEMBL16298354 | 0.90 | MMP2 (0.49) | MMP9MMP2MMP8MMP3MMP12 | |
| SCHEMBL13201330 | 0.90 | MMP8 (0.52) | MMP9MMP2MMP8MMP3MMP12 | |
| SCHEMBL13480199 | 0.90 | MMP2 (0.49) | MMP9MMP2MMP8MMP3MMP12 | |
| SCHEMBL8319435 | 0.88 | MMP2 (0.48) | MMP9MMP2MMP8MMP3MMP12 | |
| SCHEMBL8326140 | 0.87 | PSEN1 (0.52) | MMP9MMP2MMP8MMP3MMP12 | |
| SCHEMBL13201315 | 0.87 | MMP2 (0.46) | MMP9MMP2MMP3MMP12MMP1 | |
| SCHEMBL13201328 | 0.87 | CA9 (0.52) | MMP9MMP2MMP8MMP3MMP12 | |
| SCHEMBL2963202 | 0.86 | MMP2 (0.48) | MMP9MMP2MMP8MMP3MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| WO-2004060874-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |