Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.55 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 4/20 | 0.42 |
| ▸ | MMP3 | P08254 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319047 | 0.98 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5310614 | 0.96 | PSEN1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8327363 | 0.90 | MMP2 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8319435 | 0.88 | MMP2 (0.48) | ACHEMMP8MMP3ALDH1A1HTT | |
| SCHEMBL8326140 | 0.87 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2959199 | 0.85 | AKR1C3 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16298352 | 0.85 | AKR1C3 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8319431 | 0.85 | AKR1C3 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13479960 | 0.85 | AKR1C3 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13201349 | 0.85 | ACHE (0.49) | ACHEMMP8MMP3AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| WO-2004060874-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |