Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 8/20 | 0.61 |
| ▸ | MMP2 | P08253 | 7/20 | 0.61 |
| ▸ | MMP12 | P39900 | 1/20 | 0.61 |
| ▸ | MMP1 | P03956 | 19/20 | 0.60 |
| ▸ | MMP3 | P08254 | 17/20 | 0.60 |
| ▸ | MMP7 | P09237 | 15/20 | 0.60 |
| ▸ | MMP13 | P45452 | 14/20 | 0.60 |
| ▸ | MMP8 | P22894 | 1/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2963202 | 0.87 | MMP2 (0.48) | MMP9MMP2MMP12MMP1MMP3 | |
| SCHEMBL8324754 | 0.87 | MMP2 (0.48) | MMP9MMP2MMP12MMP1MMP3 | |
| SCHEMBL5532810 | 0.87 | MMP1 (0.62) | MMP9MMP2MMP12MMP1MMP3 | |
| SCHEMBL1656257 | 0.87 | MMP9 (0.68) | MMP9MMP2MMP12MMP1MMP3 | |
| SCHEMBL1656130 | 0.87 | MMP1 (0.62) | MMP9MMP2MMP12MMP1MMP3 | |
| SCHEMBL13201315 | 0.86 | MMP2 (0.46) | MMP9MMP2MMP12MMP1MMP3 | |
| SCHEMBL1655768 | 0.85 | MMP2 (0.66) | MMP9MMP2MMP12MMP1MMP3 | |
| SCHEMBL13201339 | 0.85 | MMP2 (0.46) | MMP9MMP2MMP12MMP1MMP3 | |
| SCHEMBL8319091 | 0.85 | MMP9 (0.46) | MMP9MMP2MMP12MMP1MMP3 | |
| SCHEMBL8324756 | 0.85 | MMP2 (0.46) | MMP9MMP2MMP12MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |