Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 0.48 |
| ▸ | MMP9 | P14780 | 7/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 10/20 | 0.44 |
| ▸ | MMP3 | P08254 | 9/20 | 0.44 |
| ▸ | MMP7 | P09237 | 9/20 | 0.44 |
| ▸ | MMP13 | P45452 | 8/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2963202 | 1.00 | MMP2 (0.48) | MMP2MMP9MMP12EPHX2MMP1 | |
| SCHEMBL13201315 | 0.89 | MMP2 (0.46) | MMP2MMP9MMP12EPHX2MMP1 | |
| SCHEMBL8324756 | 0.88 | MMP2 (0.46) | MMP2MMP9MMP12MMP1MMP3 | |
| SCHEMBL8319091 | 0.88 | MMP9 (0.46) | MMP2MMP9MMP12MMP1MMP3 | |
| SCHEMBL13201339 | 0.88 | MMP2 (0.46) | MMP2MMP9MMP12MMP1MMP3 | |
| SCHEMBL8319548 | 0.87 | ACHE (0.53) | MMP2MMP9MMP12EPHX2 | |
| SCHEMBL13201347 | 0.87 | MMP9 (0.61) | MMP2MMP9MMP12MMP1MMP3 | |
| SCHEMBL13479959 | 0.87 | ACHE (0.53) | MMP2MMP9MMP12EPHX2 | |
| SCHEMBL8320621 | 0.86 | POLB (0.60) | MMP2MMP9MMP12POLB | |
| SCHEMBL2964063 | 0.86 | PSEN1 (0.43) | MMP2MMP9MMP12EPHX2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7772270-B2 | Imino acid derivatives as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| WO-2004060874-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |