Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.46 |
| ▸ | MMP9 | P14780 | 10/20 | 0.46 |
| ▸ | MMP12 | P39900 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 9/20 | 0.41 |
| ▸ | MMP3 | P08254 | 8/20 | 0.41 |
| ▸ | MMP7 | P09237 | 7/20 | 0.41 |
| ▸ | MMP13 | P45452 | 6/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201315 | 0.89 | MMP2 (0.46) | MMP2MMP9MMP12MMP1MMP3 | |
| SCHEMBL8319091 | 0.88 | MMP9 (0.46) | MMP2MMP9MMP12MMP1MMP3 | |
| SCHEMBL8324754 | 0.88 | MMP2 (0.48) | MMP2MMP9MMP12MMP1MMP3 | |
| SCHEMBL2963202 | 0.88 | MMP2 (0.48) | MMP2MMP9MMP12MMP1MMP3 | |
| SCHEMBL13201339 | 0.88 | MMP2 (0.46) | MMP2MMP9MMP12MMP1MMP3 | |
| SCHEMBL8320651 | 0.86 | MMP9 (0.62) | MMP2MMP9MMP12MMP1MMP3 | |
| SCHEMBL8319548 | 0.85 | ACHE (0.53) | MMP2MMP9MMP12ALDH1A1GAA | |
| SCHEMBL16298354 | 0.85 | MMP2 (0.49) | MMP2MMP9MMP12MMP1MMP3 | |
| SCHEMBL8326181 | 0.85 | MMP8 (0.52) | MMP2MMP9MMP12MMP1MMP3 | |
| SCHEMBL13201320 | 0.85 | MMP1 (0.48) | MMP2MMP9MMP12MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004060874-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |