SCHEMBL13201484

SCHEMBL13201484

COC(=O)c1cc(OC(F)F)ccc1CBr

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 1/20 0.44
▸ TSHR P16473 1/20 0.44
▸ EPHX2 P34913 1/20 0.42
▸ PKM P14618 2/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ KDM4E B2RXH2 2/20 0.40
▸ LMNA P02545 1/20 0.40
▸ CYP1A2 P05177 1/20 0.40
▸ CYP2D6 P10635 1/20 0.40
▸ CYP2C9 P11712 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ ALOX15 P16050 1/20 0.40
▸ GFER P55789 1/20 0.40
▸ ADAM17 P78536 1/20 0.40
▸ ALDH1A1 P00352 5/20 0.39
▸ POLB P06746 1/20 0.39
▸ ATM Q13315 1/20 0.38
▸ HTT P42858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8232936 0.87 MAPT (0.45) MAPTTSHREPHX2PKMMEN1
SCHEMBL3481112 0.86 CYP4F2 (0.45) MAPTTSHRMEN1KMT2ASMN1; SMN2
SCHEMBL24391534 0.85 MRGPRX4 (0.44) EPHX2KMT2AKDM4ECYP1A2CYP2D6
SCHEMBL29937566 0.85 MRGPRX4 (0.44) EPHX2KMT2AKDM4ECYP1A2CYP2D6
SCHEMBL149036 0.84 KDM4E (0.55) MAPTPKMMEN1KMT2ASMN1; SMN2
SCHEMBL21994382 0.82 KDM4E (0.44) MAPTPKMMEN1KMT2ASMN1; SMN2
SCHEMBL27153590 0.81 XDH (0.39) MAPTTSHRKDM4ELMNACYP1A2
SCHEMBL14441468 0.81 KDM4E (0.48) MEN1KMT2ASMN1; SMN2KDM4ELMNA
SCHEMBL1813466 0.80 MAPT (0.47) MAPTTSHRPKMMEN1KMT2A
SCHEMBL30744983 0.80 MAPT (0.47) MAPTTSHRPKMMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230088968-A1 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA CROP PROTECTION AG (CH) 2023-03-23 — — US disclosed
EP-4087841-A1 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS Syngenta Crop Protection AG (CH) 2022-11-16 — — EP disclosed
CN-115023426-A Pesticidally active heterocyclic derivatives with sulfur-containing substituents 先正达农作物保护股份公司 2022-09-06 — — CN disclosed
US-7772263-B2 Compounds for the treatment of inflammatory disorders SCHERING CORPORATION (US) 2010-08-10 — — US disclosed
US-7772263-B2 Compounds for the treatment of inflammatory disorders SCHERING CORPORATION (US) 2010-08-10 — — US disclosed
US-20090156586-A1 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS SCHERING CORPORATION 2009-06-18 — — US disclosed
US-20090156586-A1 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS SCHERING CORPORATION 2009-06-18 — — US disclosed
US-7524842-B2 Compounds for the treatment of inflammatory disorders SCHERING CORPORATION (US) 2009-04-28 — — US disclosed
US-7524842-B2 Compounds for the treatment of inflammatory disorders SCHERING CORPORATION (US) 2009-04-28 — — US disclosed
US-20070197564-A1 Compounds for the treatment of inflammatory disorders SCHERING CORPORATION 2007-08-23 — — US disclosed
US-20070197564-A1 Compounds for the treatment of inflammatory disorders SCHERING CORPORATION 2007-08-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090156586-A1 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS ADAMTS1, ADAMTS13, ADAMTS7 MAPT 622/4885TSHR 3661/4885EPHX2 852/4885
US-20230088968-A1 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS DDT, ACHE, AADAC MAPT 3182/4885TSHR 3819/4885EPHX2 1537/4885
US-20070197564-A1 Compounds for the treatment of inflammatory disorders ADAMTS1, ADAMTS13, ADAMTS7 MAPT 622/4885TSHR 3661/4885EPHX2 852/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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