Sugi Predict

Sugi Predict / Compounds / SCHEMBL1320673

SCHEMBL1320673

SCHEMBL1320673

CC=Cc1cccc(C(C)=O)c1O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IAPP P10997 4/20 0.47
▸ ERN1 O75460 3/20 0.38
▸ MAPT P10636 3/20 0.38
▸ LMNA P02545 2/20 0.38
▸ NR1H4 Q96RI1 1/20 0.37
▸ KDM4E B2RXH2 3/20 0.37
▸ POLB P06746 2/20 0.37
▸ TLR2 O60603 1/20 0.37
▸ TLR1 Q15399 1/20 0.37
▸ TLR6 Q9Y2C9 1/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ NSD2 O96028 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ MCL1 Q07820 1/20 0.37
▸ THRB P10828 1/20 0.36
▸ BACE1 P56817 1/20 0.36
▸ L3MBTL1 Q9Y468 2/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ HPGD P15428 2/20 0.36
▸ HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1320671 1.00 IAPP (0.47) IAPPERN1MAPTLMNANR1H4
SCHEMBL8676074 1.00 IAPP (0.47) IAPPERN1MAPTLMNANR1H4
SCHEMBL11130587 0.85 ALDH1A1 (0.53) IAPPKDM4ETLR2TLR1TLR6
SCHEMBL11130591 0.85 ALDH1A1 (0.53) IAPPKDM4ETLR2TLR1TLR6
SCHEMBL21362675 0.84 AKR1C3 (0.44) IAPPERN1MAPTLMNANR1H4
SCHEMBL8120539 0.82 ERN1 (0.57) IAPPERN1MAPTLMNAKDM4E
SCHEMBL23226919 0.82 LMNA (0.41) IAPPMAPTLMNAKDM4EPOLB
Hydrochloric Acid SCHEMBL29912876 0.81 ERN1 (0.55) IAPPERN1MAPTLMNAKDM4E
SCHEMBL7052252 0.81 IAPP (0.47) IAPPMAPTNR1H4KDM4EPOLB
SCHEMBL7052246 0.81 IAPP (0.47) IAPPMAPTNR1H4KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2035419-B1 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS BAYER IP GMBH (DE) 2016-06-22 — — EP disclosed
US-9051316-B2 Substituted 4-aryl-1,4-dihydro-1,6-naphthyridine amides and their use BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-06-09 — — US disclosed
EP-2132206-B1 SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF BAYER IP GMBH (DE) 2015-04-01 — — EP disclosed
US-20140100243-A1 SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE AMIDES AND THEIR USE BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-04-10 — — US disclosed
US-8436180-B2 Substituted-4-aryl-1,4-dihydro-1,6-naphthyridinamides and use thereof BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-05-07 — — US disclosed
US-8404709-B2 Substituted 4-aryl-1,4-dihydro-1,6-naphthyridines and use thereof BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-03-26 — — US disclosed
US-8404723-B2 3-cyano 5-thiazaheteroaryl-dihydropyridine and the use thereof for the treatment of cardiovascular diseases BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-03-26 — — US disclosed
US-8399471-B2 Aryl-or heteroaryl-substituted pyrido[2,3-d] pyrimidines and pharmaceutical compositions of the same BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-03-19 — — US disclosed
US-8058447-B2 4-Chromenonyl-1,4-dihydropyridinecarbonitriles and the use thereof BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2011-11-15 — — US disclosed
EP-1926727-B1 4-CHROMENONYL-1,4-DIHYDROPYRIDINECARBONITRILES AND THE USE THEREOF Bayer Pharma AG (DE) 2011-09-14 — — EP disclosed
EP-2035419-A1 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS Bayer HealthCare AG (DE) 2009-03-18 — — EP disclosed
EP-2029591-A1 SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF Bayer HealthCare AG (DE) 2009-03-04 — — EP disclosed
WO-2008104306-A2 SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-09-04 — — WO disclosed
EP-1910329-A1 4-CHROMENONYL-1,4-DIHYDROPYRIDINES AND THEIR USE Bayer HealthCare AG (DE) 2008-04-16 — — EP disclosed
WO-2007140894-A1 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS BAYER HEALTHCARE AG (DE) 2007-12-13 — — WO disclosed
WO-2007140934-A1 SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF BAYER HEALTHCARE AG (DE) 2007-12-13 — — WO disclosed
WO-2007025604-A1 4-CHROMENONYL-1,4-DIHYDROPYRIDINES AND THEIR USE BAYER HEALTHCARE AG (DE) 2007-03-08 — — WO disclosed
US-5721248-A CALCIUM AGONISTS; TREATING CARDIOVASCULAR DISORDERS BAYER AKTIENGESELLSCHAFT (DE) 1998-02-24 — — US disclosed
US-5545646-A CARDIOVASCULAR DISORDERS BAYER AKTIENGESELLSCHAFT (DE) 1996-08-13 — — US disclosed
EP-0630895-A1 4-Bicyclic substituted dihydropyridines, process for their preparation and their use in medicaments BAYER AG (DE) 1994-12-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140100243-A1 SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE AMIDES AND THEIR USE NAT1, AADAC, QDPR IAPP 2153/4885ERN1 1987/4885MAPT 4370/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.