Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052252 | 1.00 | IAPP (0.47) | IAPPHSP90AB1L3MBTL1MAPTSMN1; SMN2 | |
| Cuminaldehyde SCHEMBL10805364 | 0.83 | TYR (0.44) | IAPPHSP90AB1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL21912600 | 0.83 | ERN1 (0.50) | IAPPHSP90AB1ALDH1A1HPGDHTT | |
| SCHEMBL21362675 | 0.83 | AKR1C3 (0.44) | IAPPL3MBTL1MAPTALDH1A1HPGD | |
| SCHEMBL6440974 | 0.82 | TAS1R3 (0.38) | IAPPHSP90AB1L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL11130587 | 0.81 | ALDH1A1 (0.53) | IAPPSMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL11130591 | 0.81 | ALDH1A1 (0.53) | IAPPSMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL1320673 | 0.81 | IAPP (0.47) | IAPPL3MBTL1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1320671 | 0.81 | IAPP (0.47) | IAPPL3MBTL1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8676074 | 0.81 | IAPP (0.47) | IAPPL3MBTL1MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0100250-B1 | METHYLFLAVONE DERIVATIVES | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1987-03-04 | — | — | EP | claimed |
| EP-1222183-B1 | BENZOPYRAN DERIVATIVES | RECORDATI CHEM PHARM (IT) | 2003-04-23 | — | — | EP | disclosed |
| US-20020183290-A1 | Adrenergic receptor antagonists selective for both alpha1A-and alpha1D-subtypes and uses therefor | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY | 2002-12-05 | — | — | US | disclosed |
| WO-2002060534-A2 | SELECTIVE ALPHA 1 ANTAGONISTS A + D | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA (IT) | 2002-08-08 | — | — | WO | disclosed |
| EP-1222183-A1 | BENZOPYRAN DERIVATIVES | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 2002-07-17 | — | — | EP | disclosed |
| US-6403594-B1 | UROGENTIAL INFECTIONS, ETC | RECORDATI, S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2002-06-11 | — | — | US | disclosed |
| WO-2001029022-A1 | BENZOPYRAN DERIVATIVES | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA (IT) | 2001-04-26 | — | — | WO | disclosed |
| US-5474994-A | Treating hypertension, urethral and lower urinary tract contractions | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-12-12 | — | — | US | disclosed |
| EP-0100250-B1 | METHYLFLAVONE DERIVATIVES | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1987-03-04 | — | — | EP | disclosed |
| US-4594345-A | Containing a 2-phenyl substituted chroman-4-one ring | NIPPON SHINYAKU CO. LTD. (JP) | 1986-06-10 | — | — | US | disclosed |
| EP-0100250-A2 | Methylflavone derivatives | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1984-02-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183290-A1 | Adrenergic receptor antagonists selective for both alpha1A-and alpha1D-subtypes and uses therefor | ADRB1, ADRA1D, ADRA1B | IAPP 3008/4885HSP90AB1 1049/4885L3MBTL1 1517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.