Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.55 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.55 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.55 |
| ▸ | NT5E | P21589 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636036 | 0.85 | ADORA2A (0.52) | ADORA3 | |
| SCHEMBL918591 | 0.82 | ADORA3 (0.69) | ADORA3TSHRTP53SLC29A1TDP1 | |
| SCHEMBL5859134 | 0.82 | ADORA3 (0.68) | ADORA3TSHRCYP3A4NFKB1BLM | |
| SCHEMBL5685741 | 0.82 | ADORA2A (0.61) | ADORA3TSHRTP53SLC29A1TDP1 | |
| SCHEMBL7744261 | 0.81 | AHCY (0.46) | — | |
| SCHEMBL7161647 | 0.81 | ADORA2A (0.63) | ADORA3TSHRTP53SLC29A1TDP1 | |
| SCHEMBL29877256 | 0.81 | AHCY (0.61) | ADORA3TSHRDOT1LBLM | |
| SCHEMBL177772 | 0.81 | AHCY (0.61) | ADORA3TSHRDOT1LBLM | |
| SCHEMBL28901883 | 0.81 | AHCY (0.61) | ADORA3TSHRDOT1LBLM | |
| SCHEMBL27437734 | 0.80 | ADORA3 (0.76) | ADORA3TSHRTP53SLC29A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058243-B2 | Method for treating a brain cancer with ifenprodil | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2011-11-15 | — | — | US | disclosed |
| US-20090076019-A1 | METHODS FOR TREATING NEUROLOGICAL DISORDERS OR DAMAGE | MOUNT SINAI HOSPITAL (CA) | 2009-03-19 | — | — | US | disclosed |