Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.37 |
| ▸ | USP10 | Q14694 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | CRHBP | P24387 | 2/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3114745 | 0.81 | KMT2A (0.42) | ALDH1A1L3MBTL1USP10MAPTMAPK1 | |
| SCHEMBL13221961 | 0.74 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL28250511 | 0.74 | ALDH1A1 (0.48) | ALDH1A1USP10MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL13221951 | 0.71 | KMT2A (0.50) | ALDH1A1USP10MAPTSMN1; SMN2KMT2A | |
| SCHEMBL13221948 | 0.71 | VCAM1 (0.43) | ALDH1A1L3MBTL1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL12427995 | 0.69 | L3MBTL1 (0.42) | ALDH1A1L3MBTL1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL27987013 | 0.66 | ALDH1A1 (0.63) | ALDH1A1L3MBTL1MAPTSMN1; SMN2GAA | |
| SCHEMBL10091749 | 0.66 | ALDH1A1 (0.77) | ALDH1A1L3MBTL1MAPTSMN1; SMN2GAA | |
| SCHEMBL3341806 | 0.66 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL30563095 | 0.66 | HSD17B10 (0.50) | ALDH1A1L3MBTL1MAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100210639-A1 | 9H-PYRIMIDO[4,5-B]INDOLES, 9H-PYRIDO[4',3':4,5]PYRROLO[2,3-D]PYRIDINES, AND 9H 1,3,6,9 TETRAAZA-FLUORENES AS CHK1 KINASE FUNCTION INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210639-A1 | 9H-PYRIMIDO[4,5-B]INDOLES, 9H-PYRIDO[4',3':4,5]PYRROLO[2,3-D]PYRIDINES, AND 9H 1,3,6,9 TETRAAZA-FLUORENES AS CHK1 KINASE FUNCTION INHIBITORS | CHEK1, CHEK2, PLK1 | ALDH1A1 2087/4885L3MBTL1 1351/4885USP10 2941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.