Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 3/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.47 |
| ▸ | SCN1A | P35498 | 2/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1322297 | 0.99 | GRIN2D (0.46) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL12123177 | 0.92 | GRIN2D (0.46) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Cns-5161 SCHEMBL499356 | 0.90 | GRIN2D (0.54) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Cns-5161 SCHEMBL29370312 | 0.90 | GRIN2D (0.54) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Cns-5161 SCHEMBL6420655 | 0.89 | GRIN2D (0.53) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL7202740 | 0.88 | GRIN2D (0.49) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL2593943 | 0.87 | GRIN2D (0.51) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Hydrochloric Acid SCHEMBL7208221 | 0.87 | GRIN2D (0.48) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL12125153 | 0.86 | GRIN2D (0.48) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL6847556 | 0.84 | HSD17B1 (0.47) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896400-B1 | 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES FOR USE IN MEDICAL IMAGING | HAMMERSMITH IMANET LTD (GB) | 2013-10-16 | — | — | EP | claimed |
| US-20100143252-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | GE HEALTHCARE LIMITED (GB) | 2010-06-10 | — | — | US | claimed |
| EP-1896400-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | Hammersmith Imanet, Ltd (GB) | 2008-03-12 | — | — | EP | claimed |
| WO-2006136846-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | HAMMERSMITH IMANET LIMITED (GB) | 2006-12-28 | — | — | WO | claimed |
| US-10759747-B2 | Alkylation method | GE HEALTHCARE LIMITED (GB) | 2020-09-01 | — | — | US | disclosed |
| EP-2766325-B1 | METHOD FOR THE SYNTHESIS OF 18F-LABELLED BIOMOLECULES | GE HEALTHCARE LTD (GB) | 2020-03-18 | — | — | EP | disclosed |
| US-20190161440-A1 | ALKYLATION METHOD | KINGS COLLEGE LONDON (GB) | 2019-05-30 | — | — | US | disclosed |
| WO-2017186969-A1 | ALKYLATION METHOD | GE HEALTHCARE LIMITED (GB) | 2017-11-02 | — | — | WO | disclosed |
| US-9125954-B2 | Method for the synthesis of 18F-labelled biomolecules | GE HEALTHCARE LIMITED (GB) | 2015-09-08 | — | — | US | disclosed |
| US-9085518-B2 | Method for the synthesis of 18F-labelled molecules | GE HEALTHCARE LIMITED (GB) | 2015-07-21 | — | — | US | disclosed |
| US-9085518-B2 | Method for the synthesis of 18F-labelled molecules | GE HEALTHCARE LIMITED (GB) | 2015-07-21 | — | — | US | disclosed |
| US-20140243555-A1 | METHOD FOR THE SYNTHESIS OF 18F-LABELLED MOLECULES | GE HEALTHCARE LIMITED (GB) | 2014-08-28 | — | — | US | disclosed |
| WO-2011141568-A1 | METHOD OF SYNTHESIS | GE HEALTHCARE LIMITED (GB) | 2011-11-17 | — | — | WO | disclosed |
| WO-2011141568-A1 | METHOD OF SYNTHESIS | GE HEALTHCARE LIMITED (GB) | 2011-11-17 | — | — | WO | disclosed |
| US-8058311-B2 | Imaging 18F or 11C-labelled alkylthiophenyl guanidines | HAMMERSMITH IMANET LIMITED (GB) | 2011-11-15 | — | — | US | disclosed |
| US-8058311-B2 | Imaging 18F or 11C-labelled alkylthiophenyl guanidines | HAMMERSMITH IMANET LIMITED (GB) | 2011-11-15 | — | — | US | disclosed |
| US-20100143252-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | GE HEALTHCARE LIMITED (GB) | 2010-06-10 | — | — | US | disclosed |
| US-20100143252-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | GE HEALTHCARE LIMITED (GB) | 2010-06-10 | — | — | US | disclosed |
| EP-1896400-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | Hammersmith Imanet, Ltd (GB) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006136846-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | HAMMERSMITH IMANET LIMITED (GB) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243555-A1 | METHOD FOR THE SYNTHESIS OF 18F-LABELLED MOLECULES | GMPS, PAICS, DUT | GRIN2D 4038/4885GRIN3B 3672/4885GRIN1 4777/4885 |
| US-10759747-B2 | Alkylation method | INMT, ALKBH3, PIGO | GRIN2D 3331/4885GRIN3B 1939/4885GRIN1 3197/4885 |
| US-20190161440-A1 | ALKYLATION METHOD | INMT, ALKBH3, PIGO | GRIN2D 3331/4885GRIN3B 1939/4885GRIN1 3197/4885 |
| US-20100143252-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | SSTR3, GPR3, GALR3 | GRIN2D 649/4885GRIN3B 326/4885GRIN1 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.