Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27604391 | 0.75 | TSHR (0.37) | TSHRALDH1A1TDP1CA5ACA5B | |
| SCHEMBL11776563 | 0.71 | TSHR (0.39) | TSHRALDH1A1TDP1CA5ACA5B | |
| SCHEMBL28195472 | 0.71 | TSHR (0.39) | TSHRALDH1A1TDP1CA5ACA5B | |
| SCHEMBL16099341 | 0.71 | — | — | |
| SCHEMBL11147400 | 0.69 | TSHR (0.37) | TSHRALDH1A1TDP1CA5ACA5B | |
| SCHEMBL3512371 | 0.69 | TSHR (0.37) | TSHRALDH1A1TDP1CA5ACA5B | |
| SCHEMBL28457846 | 0.68 | — | — | |
| SCHEMBL4669135 | 0.67 | — | — | |
| SCHEMBL8161200 | 0.67 | ALDH1A1 (0.35) | TSHRALDH1A1TDP1CA5ACA5B | |
| SCHEMBL7872758 | 0.67 | ALDH1A1 (0.43) | TSHRALDH1A1TDP1CA5ACA5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415487-B2 | Process for preparing (3R)-2′-(4-bromo-2-fluorobenzyl)spiro-[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-A]pyrazine]-1′,2,3′,5(2H′)-tetraone | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-04-09 | — | — | US | disclosed |
| US-20120010405-A1 | OPTICALLY ACTIVE 3-AMINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATE, PROCESS FOR PRODUCTION OF THE COMPOUND, AND USE OF THE COMPOUND | TANAKA DAISUKE (JP) | 2012-01-12 | — | — | US | disclosed |
| US-8058456-B2 | Optically active 3-amino-2,5-dioxopyrrolidine-3-carboxylate, process for production of the compound, and use of the compound | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-11-15 | — | — | US | disclosed |
| US-20090286980-A1 | OPTICALLY ACTIVE 3-AMINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATE, PROCESS FOR PRODUCTION OF THE COMPOUND, AND USE OF THE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-11-19 | — | — | US | disclosed |
| EP-0839805-B1 | Pyrrolidinone derivatives and their use as antipsychotic medicaments | SCHERING AG (DE) | 2001-10-04 | — | — | EP | disclosed |
| US-5969138-A | ANTIPSYCHOTIC AGENTS | MITSUI CHEMICALS, INC. (JP) | 1999-10-19 | — | — | US | disclosed |
| EP-0839805-A1 | Pyrrolidinone derivatives and their use as antipsychotic medicaments | MITSUI TOATSU CHEMICALS, INC. (JP) | 1998-05-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286980-A1 | OPTICALLY ACTIVE 3-AMINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATE, PROCESS FOR PRODUCTION OF THE COMPOUND, AND USE OF THE COMPOUND | REN, GPR119, RANBP1 | TSHR 2500/4885ALDH1A1 702/4885TDP1 4548/4885 |
| US-20120010405-A1 | OPTICALLY ACTIVE 3-AMINO-2,5-DIOXOPYRROLIDINE-3-CARBOXYLATE, PROCESS FOR PRODUCTION OF THE COMPOUND, AND USE OF THE COMPOUND | REN, GPR119, RANBP1 | TSHR 2500/4885ALDH1A1 702/4885TDP1 4548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.