Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2232346 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2GAATDP1KMT2AKDM4E | |
| SCHEMBL16841477 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2GAATDP1KMT2AKDM4E | |
| SCHEMBL16841467 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2GAATDP1KMT2AKDM4E | |
| SCHEMBL19315873 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2GAATDP1KMT2AKDM4E | |
| SCHEMBL19386548 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2GAATDP1KMT2AKDM4E | |
| SCHEMBL28243791 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2GAATDP1KMT2AKDM4E | |
| SCHEMBL19919700 | 0.77 | FFAR3 (0.54) | SMN1; SMN2GAATDP1GRM2GRM3 | |
| SCHEMBL25001002 | 0.76 | SMN1; SMN2 (0.38) | SMN1; SMN2GAATDP1KMT2AKDM4E | |
| SCHEMBL19807106 | 0.76 | KDM4E (0.39) | SMN1; SMN2GAATDP1KMT2AKDM4E | |
| SCHEMBL16552279 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2GAATDP1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100166819-A1 | Transforming Growth Factor Modulators | BIOGEN IDEC MA INC. A CORPORATION | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100166819-A1 | Transforming Growth Factor Modulators | ACVR1, TGFBR1, ACVRL1 | SMN1; SMN2 4638/4885GAA 3308/4885TDP1 4499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.