Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.54 |
| ▸ | MAOA | P21397 | 6/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27732887 | 0.78 | MAOB (0.54) | MAOBMAOAROCK2GRK2SIRT2 | |
| SCHEMBL1322320 | 0.73 | RAB9A (0.49) | MAPTMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL11506421 | 0.72 | JAK2 (0.38) | MEN1KMT2A | |
| SCHEMBL8985182 | 0.71 | ALDH1A1 (0.42) | MAPTHTTMEN1KMT2AKDM4E | |
| SCHEMBL332623 | 0.71 | MAOA (0.63) | MAOBMAOAMEN1KMT2AKDM4E | |
| SCHEMBL6679870 | 0.71 | MAPT (0.43) | MAOBMAOAROCK2GRK2MAPT | |
| SCHEMBL19973146 | 0.71 | MAOA (0.51) | MAOBMAOASLC6A4CYP3A4HSD17B10 | |
| SCHEMBL34461889 | 0.70 | MAOB (1.00) | MAOBMAOAMAPTMEN1KMT2A | |
| SCHEMBL11498323 | 0.70 | MAOA (0.47) | MAOBMAOAROCK2GRK2MAPT | |
| SCHEMBL1322419 | 0.70 | MAOB (0.51) | MAOBMAOASIRT2SLC6A4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896400-B1 | 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES FOR USE IN MEDICAL IMAGING | HAMMERSMITH IMANET LTD (GB) | 2013-10-16 | — | — | EP | disclosed |
| EP-1896400-B1 | 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES FOR USE IN MEDICAL IMAGING | HAMMERSMITH IMANET LTD (GB) | 2013-10-16 | — | — | EP | disclosed |
| US-8058311-B2 | Imaging 18F or 11C-labelled alkylthiophenyl guanidines | HAMMERSMITH IMANET LIMITED (GB) | 2011-11-15 | — | — | US | disclosed |
| US-8058311-B2 | Imaging 18F or 11C-labelled alkylthiophenyl guanidines | HAMMERSMITH IMANET LIMITED (GB) | 2011-11-15 | — | — | US | disclosed |
| US-8058311-B2 | Imaging 18F or 11C-labelled alkylthiophenyl guanidines | HAMMERSMITH IMANET LIMITED (GB) | 2011-11-15 | — | — | US | disclosed |
| US-20100143252-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | GE HEALTHCARE LIMITED (GB) | 2010-06-10 | — | — | US | disclosed |
| US-20100143252-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | GE HEALTHCARE LIMITED (GB) | 2010-06-10 | — | — | US | disclosed |
| US-20100143252-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | GE HEALTHCARE LIMITED (GB) | 2010-06-10 | — | — | US | disclosed |
| EP-1896400-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | Hammersmith Imanet, Ltd (GB) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006136846-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | HAMMERSMITH IMANET LIMITED (GB) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100143252-A1 | IMAGING 18F OR 11C-LABELLED ALKYLTHIOPHENYL GUANIDINES | SSTR3, GPR3, GALR3 | MAOB 1712/4885MAOA 2511/4885ROCK2 2291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.